Clinical and pathological observation of conversion therapy for malignant peritoneal mesothelioma: a case report and literature review

作者：Minying Deng, Xinyi Zhang, Xu Chen, Rongkui Luo, Lingli Chen, Yuhong Zhou, Yingyong Hou · 发表于：Pathology & Oncology Research · 年份：2024 · DOI：10.3389/pore.2023.1611577 · 被引用次数：9 · 研究领域：Occupational and environmental lung diseases、Pleural and Pulmonary Diseases、Medical Imaging and Pathology Studies

Background: Malignant mesothelioma (MM) is a tumor originating from the pleura, peritoneum, or pericardial cavity. It is divided into diffuse and localized malignant mesothelioma, with four subtypes in diffuse MM: epithelioid, sarcomatoid, desmoplastic, and biphasic, with biphasic being less common. The onset of this tumor is insidious, and the prognosis is extremely poor in some cases, with a median survival of 6–18 months and no standard treatment options in the past. Aims: We report a case of peritoneal malignant mesothelioma that was successfully treated with transformative therapy. We also review the literature in the hope of providing reference for the treatment and pathological diagnosis of such patients. Methods: The case of the peritoneal malignant mesothelioma was processed and reported in the routine manner for biopsy specimens at different stages. Results and conclusion: We report a case of a malignant tumor originating in the hepatorenal recess, which was diagnosed as biphasic malignant mesothelioma through a biopsy. Immunohistochemical testing showed PD-L1 expression. After multidisciplinary discussion, the patient received transformative treatment, including a trial of combined immunotherapy. The tumor significantly shrank, and the patient obtained a chance for curative surgical resection. Microscopic examination showed significant collagenization in the lesion area, with almost no residual tumor. After 19 months of comprehensive treatment, the patient develope...