Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

作者：Lei Han, Zijing Wang, Daqi Wang, Ziwen Gao, Shaowei Hu, Dazhi Shi, Yilai Shu · 发表于：Frontiers in Cell and Developmental Biology · 年份：2024 · DOI：10.3389/fcell.2023.1305433 · 被引用次数：11 · 研究领域：Hearing, Cochlea, Tinnitus, Genetics、Vestibular and auditory disorders、Calcium signaling and nucleotide metabolism

Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with a long-term clinical therapy. The mechanism and prevention of the ototoxicity of aminoglycosides are still limited although amounts of studies explored widely. Specifically, advancements in programmed cell death (PCD) provide more new perspectives. This review summarizes the general signal pathways in programmed cell death, including apoptosis, autophagy, and ferroptosis, as well as the mechanisms of aminoglycoside-induced ototoxicity. Additionally, novel interventions, especially gene therapy strategies, are also investigated for the prevention or treatment of aminoglycoside-induced hearing loss with prospective clinical applications.