Magnesium–ibogaine therapy in veterans with traumatic brain injuries

作者：Kirsten Cherian, Jackob N. Keynan, Lauren Anker, Afik Faerman, Randi Brown, Ahmed Shamma, Or Keynan, John P. Coetzee, Jean-Marie Batail, Angela Phillips, Nicholas J. Bassano, Gregory L. Sahlem, José Inzunza, Trevor Millar, Jonathan Dickinson, Cleo E. Rolle, Jennifer Keller, Maheen M. Adamson, Ian H. Kratter, Nolan Williams · 发表于：Nature Medicine · 年份：2024 · DOI：10.1038/s41591-023-02705-w · 被引用次数：71 · 研究领域：Nicotinic Acetylcholine Receptors Study、Psychedelics and Drug Studies、Treatment of Major Depression

Abstract Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD), depression and anxiety. Special Operations Forces (SOF) veterans (SOVs) may be at an elevated risk for these complications, leading some to seek underexplored treatment alternatives such as the oneirogen ibogaine, a plant-derived compound known to interact with multiple neurotransmitter systems that has been studied primarily as a treatment for substance use disorders. Ibogaine has been associated with instances of fatal cardiac arrhythmia, but coadministration of magnesium may mitigate this concern. In the present study, we report a prospective observational study of the Magnesium–Ibogaine: the Stanford Traumatic Injury to the CNS protocol (MISTIC), provided together with complementary treatment modalities, in 30 male SOVs with predominantly mild TBI. We assessed changes in the World Health Organization Disability Assessment Schedule from baseline to immediately (primary outcome) and 1 month (secondary outcome) after treatment. Additional secondary outcomes included changes in PTSD (Clinician-Administered PTSD Scale for DSM-5), depression (Montgomery–Åsberg Depression Rating Scale) and anxiety (Hamilton Anxiety Rating Scale). MISTIC resulted in significant improvements in functioning both immediately ( P corrected < 0.001, Cohen’s d = 0.74) and 1 month ( P corrected < 0.001, d = 2.20) afte...