International consensus on post-transplantation diabetes mellitus

作者：Adnan Sharif, Harini A. Chakkera, Aiko P. J. de Vries, Kathrin Eller, Martina Guthoff, Maria C. Haller, Mads Hornum, Espen Nordheim, Alexandra Kautzky‐Willer, Michael Krebs, Aleksandra Kukla, Amelie Kurnikowski, Elisabeth Schwaiger, Núria Montero, Julio Pascual, Trond Geir Jenssen, Esteban Porrini, Manfred Hecking · 发表于：Nephrology Dialysis Transplantation · 年份：2023 · DOI：10.1093/ndt/gfad258 · 被引用次数：110 · 研究领域：Renal Transplantation Outcomes and Treatments、Transplantation: Methods and Outcomes、Diabetes Treatment and Management

Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held from 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous reports. This update includes opinion statements concerning optimal diagnostic tools, recognition of prediabetes (impaired fasting glucose and/or impaired glucose tolerance), new mechanistic insights, immunosuppression modification, evidence-based strategies to prevent PTDM, treatment hierarchy for incorporating novel glucose-lowering agents and suggestions for the future direction of PTDM research to address unmet needs. Due to the paucity of good quality evidence, consensus meeting participants agreed that making GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) recommendations would be flawed. Although kidney-allograft centric, we suggest that these opinion statements can be appraised by the transplantation community for implementat...