LCN2: Versatile players in breast cancer

作者：Yuxiang Bao, Zhongliang Yan, Nianmei Shi, Xiao‐Yan Tian, Jiayang Li, Taolang Li, Xiaoming Cheng, Junyuan Lv · 发表于：Biomedicine & Pharmacotherapy · 年份：2024 · DOI：10.1016/j.biopha.2023.116091 · 被引用次数：31 · 研究领域：Neonatal Respiratory Health Research、S100 Proteins and Annexins、Immune cells in cancer

Lipocalin 2 (LCN2) is a secreted glycoprotein that is produced by immune cells, including neutrophils and macrophages. It serves various functions such as transporting hydrophobic ligands across the cellular membrane, regulating immune responses, keeping iron balance, and fostering epithelial cell differentiation. LCN2 plays a crucial role in several physiological processes. LCN2 expression is upregulated in a variety of human diseases and cancers. High levels of LCN2 are specifically linked to breast cancer (BC) cell proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, chemotherapy resistance, and prognosis. As a result, LCN2 has gained attention as a potential therapeutic target for BC. This article offered an in-depth review of the advancement of LCN2 in the context of BC occurrence and development.