Axial length to corneal radius of curvature ratio and refractive error in Chinese preschoolers aged 4–6 years: a retrospective cross-sectional study

作者：Tao Tang, Heng Zhao, Duanke Liu, Xuewei Li, Kai Wang, Yan Li, Mingwei Zhao · 发表于：BMJ Open · 年份：2023 · DOI：10.1136/bmjopen-2023-075115 · 被引用次数：14 · 研究领域：Ophthalmology and Visual Impairment Studies、Corneal surgery and disorders、Ocular Surface and Contact Lens

OBJECTIVE: This study aims to investigate the associations of axial length to corneal radius of curvature (AL/CRC) ratio with refractive error and to determine the effect of AL/CRC ratio on hyperopia reserve and myopia assessment among Chinese preschoolers. METHODS: This was a retrospective cross-sectional study that evaluated subjects aged 4-6 years. AL and CRC were obtained using a non-contact ocular biometer. Correlation analysis was performed to explore the associations of AL/CRC ratio with spherical equivalent refractive error (SER). The accuracy of AL/CRC ratio for hyperopia reserve and myopia assessment was analysed using cycloplegic refraction by drawing receiver operating characteristic (ROC) curves. RESULTS: The analysis included 1024 participants (537 boys, 52.4%). The mean AL/CRC ratios in hyperopes, emmetropes and myopes were 2.90±0.06, 2.95±0.05 and 3.08±0.07, respectively. The SER was found to be more strongly correlated with AL/CRC ratio (ρ=-0.66, p<0.001) than either AL or CRC alone (ρ=-0.52, p<0.001; ρ=-0.03, p=0.33, respectively). AL/CRC was correlated with SER in hyperopes (ρ=-0.54, p<0.001), emmetropes (ρ=-0.33, p<0.001) and myopes (r=-0.67, p<0.001). For low hyperopia reserve assessment, the area under the ROC curves of AL/CRC ratio was 0.861 (95% CI 0.829 to 0.892), the optimal cut-off value of the AL/CRC ratio was ≥2.955. For myopia assessment, the area under the ROC curves of AL/CRC ratio was 0.954 (95% CI 0.925 to 0.982), the optimal cut-off value of...