Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

作者：Wen Liu, Li‐Ju Wang, Qin Yuan, Wei Hao, Yitao Wang, Ding‐Tao Wu, Xiaojia Chen, Shengpeng Wang · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d3fo04430k · 被引用次数：36 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Ginseng Biological Effects and Applications

. In addition, untargeted fecal metabolomic analysis revealed distinct modulation patterns of ABP-1 and ABP-2. ABP-1 mainly enriched steroid hormone biosynthesis, while ABP-2 significantly enriched bile secretion and tryptophan metabolism. In summary, ABPs, especially low-molecular-weight fraction, represent novel prebiotics for treatment of inflammatory gastrointestinal diseases.