The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample

作者：Indrit Bègue, Yannis Elandaloussi, Farnaz Delavari, Hengyi Cao, Alexandra B. Moussa‐Tooks, Mathilde Roser, Pierrick Coupé, Marion Leboyer, Stefan Kaiser, Josselin Houenou, Roscoe O. Brady, Charles Laidi · 发表于：The Cerebellum · 年份：2023 · DOI：10.1007/s12311-023-01645-y · 被引用次数：26 · 研究领域：Vestibular and auditory disorders、Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies

Multiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonical correlation analyses (CCA) examined regional gray matter volumetric (GMV) differences in association to cognitive function (quantified with NIH Toolbox Cognition domain, NIH-TB), accounting for psychopathology severity, age, sex, scan location, and intracranial volume. Multivariate CCA uncovered a significant correlation between two components entailing a latent cognitive canonical (NIH-TB subscales) and a brain canonical variate (cerebellar GMV and intracranial volume, ICV), surviving bootstrapping and permutation procedures. The components correspond to partly shared cerebellar-cognitive function relationship with a first map encompassing cognitive flexibility (r = 0.89), speed of processing (r = 0.65), and working memory (r = 0.52) associated with regional GMV in crus II (r = 0.57) and lobule X (r = 0.59) and a second map including the crus I (r = 0.49) and lobule VI (r = 0.49) associated with working memory (r = 0.51). We show evidence fo...