Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

作者：Maxime Taquet, Zuzanna Skórniewska, Henrik Zetterberg, John Geddes, Catherine Mummery, James D. Chalmers, Ling‐Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth Saunders, Victoria Harris, Linzy Houchen-Wolloff, Parisa Mansoori, Neil Greening, Ewen M. Harrison, Annemarie B Docherty, Nazir Lone, Jennifer K Quint, William Greenhalf, Louise V. Wain, Christopher E. Brightling, Rachael E Evans, Paul J. Harrison, Ivan Koychev, PHOSP-COVID Study Collaborative Group, C E Brightling, R A Evans, L V Wain, J D Chalmers, Victoria Harris, Ling‐Pei Ho, A Horsley, M Marks, K Poinasamy, Betty Raman, A Shikotra, A Singapuri, Christopher E. Brightling, Rachael A Evans, Louise V. Wain, Rowan Dowling, C Edwardson, Omer Elneima, Simon J. Finney, N J Greening, B Hargadon, Victoria Harris, Linzy Houchen-Wolloff, Olivia C. Leavy, Hamish McAuley, Christopher E. Overton, Tatiana Plekhanova, R M Saunders, M Sereno, A Singapuri, A Shikotra, Chris Taylor, S. Terry, Catherine Tong, Benhua Zhao, D Lomas, Elizabeth Sapey, C Berry, Charlotte E. Bolton, Nigel J. Brunskill, Edwin R. Chilvers, Ratko Djukanović, Y Ellis, Daniel Forton, Neil French, Jon C. George, N A Hanley, N Hart, Lorcan McGarvey, Nick Maskell, Helen McShane, Miles Parkes, D. Peckham, Paul Pfeffer, Avan Aihie Sayer, Aziz Sheikh, A. A. Roger Thompson, Nicholas S. G. Williams, Christopher E. Brightling, W Greenhalf, Malcolm G. Semple, Milton Ashworth, Hayley Hardwick, Lara Lavelle-Langham, Will Reynolds, M Sereno, R M Saunders, A Singapuri, Victoria Shaw, A Shikotra, B Venson, L V Wain, A B Docherty, Ewan M. Harrison, Aziz Sheikh, J K Baillie, Christopher E. Brightling, Luke Daines, Robert C. Free, R A Evans, S Kerr, O C Leavy, N I Lone, Hamish McAuley, Riinu Pius, J Quint, Matthew Richardson, M Sereno, Mathew Thorpe, L V Wain, Mark Halling‐Brown, Fergus Gleeson, J Jacob, S Neubauer, Betty Raman, S Siddiqui, J M Wild, S Aslani, Peter Jezzard, H. Lamlum, W. Lilaonitkul, Elizabeth M. Tunnicliffe, J Willoughby, Louise V. Wain, J K Baillie, Helen Baxendale, Christopher E. Brightling, M Brown, J D Chalmers, R A Evans, Bibek Gooptu, William Greenhalf, H E Hardwick, Gísli Jenkins, D. Jones, Ivan Koychev, Claudia Langenberg, A Lawrie, P L Molyneaux, A Shikotra, John E. Pearl, Markus Ralser, Naveed Sattar, R M Saunders, J T Scott, T. Shaw, Daniel Thomas, Dean Wilkinson, Liam G. Heaney, Anthony De Soyza, Davies Adeloye, Christopher E. Brightling, J S Brown, John Busby, J D Chalmers, C Echevarria, Luke Daines, Omer Elneima, R A Evans, John R. Hurst, Petr Novotný, Paul Pfeffer, K Poinasamy, J Quint, Igor Rudan, Elizabeth Sapey, Manu Shankar‐Hari, A Sheikh, S Siddiqui, S Walker, Bang Zheng, J R Geddes, Matthew Hotopf, Kathryn M. Abel, Rizwan Ahmed, L. Allan, C Armour, David Baguley, David Baldwin, Clive Ballard, Kamaldeep Bhui, Gerome Breen, Matthew R. Broome, Traolach Brugha, Edward T. Bullmore, David J. Burn, Felicity Callard, J. Cavanagh, Trudie Chalder, Diane Clark, Anda David, J.F.W. Deakin, Hannah Dobson, Brian Elliott, Jonathan Evans, Richard Francis, Elspeth Guthrie, Paul J. Harrison, M Henderson, Akram A. Hosseini, Nathan T. M. Huneke, Masud Husain, Thomas Jackson, Ian A. Jones, Tousif Kabir, Pádraig T. Kitterick, Ania Korszun, Ivan Koychev, Janice Kwan, Anne Lingford‐Hughes, Parisa Mansoori, R. Hamish McAllister‐Williams, K McIvor, Lea Milligan, Richard Morriss, Elizabeta B. Mukaetova‐Ladinska, Kevin J. Munro, Alejo Nevado‐Holgado, Timothy R. Nicholson, Stella‐Maria Paddick, Carmine M. Pariante, John Pimm, Kathryn J. Saunders, Michael Sharpe, Gemma Simons, Rachel Upthegrove, Simon Wessely, Gerry P McCann, Shannon Amoils, Charalambos Antoniades, Amitava Banerjee, Robert M. Bell, Anda Bularga, C Berry, Phil Chowienczyk, John P. Greenwood, Alun D. Hughes, K Khunti, L. Kingham, Cathy Lawson, Kenneth Mangion, Nicholas L. Mills, Alastair J. Moss, S Neubauer, B Raman, Amar Sattar, Cathie Sudlow, Mark Toshner, Peter Openshaw, Doris Altmann, J. Kenneth Baillie, Rachel L. Batterham, Helen Baxendale, Nicolette C. Bishop, C E Brightling, Philip C. Calder, R A Evans, Jonathan L. Heeney, Tracy Hussell, Paul Klenerman, Janet M. Lord, Peter Moss, Sarah Rowland‐Jones, Wilhelm Schwaeble, Malcolm G. Semple, Ryan S. Thwaites, L Turtle, L V Wain, Sharon Walmsley, David C. Wraith, Mugsien Rowland, Anthony Rostron, J K Baillie, Bronwen Connolly, A B Docherty, N I Lone, Daniel F. McAuley, Dhruv Parekh, Anthony Rostron, J Simpson, Charlotte Summers, Gísli Jenkins, J Porter, R Allen, Raminder Aul, J K Baillie, Shaney Barratt, Paul Beirne, John Blaikley, Rachel C. Chambers, Nazia Chaudhuri, Christopher M. Coleman, Emma Denneny, Laura Fabbri, Peter M. George, Michael Gibbons, F Gleeson, Bibek Gooptu, B Guillen Guio, Isabella Hall, N A Hanley, Ling‐Pei Ho, E Hufton, J Jacob, Ian Jarrold, G Jenkins, S Johnson, Mark G. Jones, S Jones, Faez Iqbal Khan, Puja Mehta, J Mitchell, P L Molyneaux, John E. Pearl, Karen Piper Hanley, K Poinasamy, J Quint, D Parekh, Pilar Rivera‐Ortega, Laura Saunders, Malcolm G. Semple, Jennifer Simpson, Darren Smith, Mark Spears, Lisa Spencer, Stefan Stanel, Iain Stewart, A. A. Roger Thompson, David Thickett, Ryan S. Thwaites, L V Wain, S Walker, S Walsh, J M Wild, D G Wootton, L Wright, Simon Heller, M J Davies, H. Atkins, S. Bain, J Dennis, Khalida Ismail, Desmond G. Johnston, Partha Kar, Kamlesh Khunti, Claudia Langenberg, Paul McArdle, Andrew McGovern, Tim Peto, John R. Petrie, Eleanor Robertson, Naveed Sattar, Karishma Shah, Jonathan Valabhji, Bob Young, L S Howard, Mark Toshner, C Berry, Phil Chowienczyk, Daniel Lasserson, A Lawrie, O C Leavy, J Mitchell, Lesley Price, J Quint, J Rossdale, Naveed Sattar, Cathie Sudlow, A A R Thompson, Jim M. Wild, Martin R. Wilkins, S J Singh, William D‐C Man, J M Lord, N J Greening, Trudie Chalder, J T Scott, Natalie Armstrong, Eileen Baldry, Molly M Baldwin, N Basu, Michael Beadsworth, Lisa Bishop, Charlotte E. Bolton, Andrew Briggs, Mamta Buch, Gail Carson, J. Cavanagh, Hector Chinoy, E Daynes, Sylviane Defres, R A Evans, Paul L. Greenhaff, Sharlene A. Greenwood, M Harvie, Masud Husain, Steven MacDonald, Anne McArdle, Hamish McAuley, Anne McMahon, Melitta A. McNarry, Claire M. Nolan, Catherine O’Donnell, D Parekh, John Pimm, J Sargent, Louise Sigfrid, Michael Steiner, David J. Stensel, A L Tan, Julie Whitney, Dean Wilkinson, Daisy Wilson, Miles D. Witham, D G Wootton, T Yates, Daniel Thomas, N Brunskill, Sarah Francis, Sharlene A. Greenwood, Charles Laing, Kate Bramham, Papia Chowdhury, Adam Frankel, L Lightstone, Stephen P. McAdoo, Kieran McCafferty, Marlies Ostermann, Nicholas M. Selby, Claire C. Sharpe, Michelle Willicombe, Alison Shaw, Lará Armstrong, Brigid Hairsine, H Henson, C Kurasz, L Shenton, Sara Fairbairn, Amanda Dell, N Hawkings, J Haworth, M Hoare, Alice Lucey, Victoria Lewis, Georgia Mallison, H Nassa, Catherine Pennington, Angeline Price, Christopher P. Price, A. Storrie, Guillermo B. Willis, Scott Young, Paul Pfeffer, K Chong-James, C David, W Y James, Adrian R. Martineau, O Zongo, Amanda Sanderson, Liam G. Heaney, C Armour, Verity J. Brown, Thelma Craig, S Drain, Bernadette King, N Magee, D McAulay, Eugene O. Major, Lorcan McGarvey, J McGinness, Richard Stone, A Haggar, A Bolger, Ffyon Davies, Joanne Lewis, Adam Lloyd, R Manley, E McIvor, Daniel Menzies, Kathryn J. Roberts, W Saxon, David Southern, Christian P Subbe, Victor Whitehead, H El-Taweel, Jennifer Dawson, Leanne J. Robinson, Dinesh Saralaya, L Brear, Karen Regan, Kim Storton, Jonathan Fuld, Areti Bermperi, Isabel Cruz, K Dempsey, A Elmer, H Jones, S Jose, Stefan J. Marciniak, Miles Parkes, Carla Ribeiro, J. Paul Taylor, Mark Toshner, Lea C. Watson, J Worsley, R. Sabit, L Broad, A Buttress, Teriann Evans, M Haynes, L Jones, Lucy Knibbs, Alison McQueen, C Oliver, Kerry Paradowski, John Williams, Emma Harris, Claire Sampson, C. Lynch, Elin Haf Davies, C Evenden, A Hancock, Kerry Hancock, Megan Rees, L Roche, Natalie Stroud, T Thomas-Woods, Marta Babores, Joanne Bradley-Potts, M Holland, Natalie Keenan, S Shashaa, Helen Wassall, Eva Beranová, H Weston, Tracey Cosier, Luke Austin, J Deery, T Hazelton, Christopher P. Price, Heiler Lozada Ramos, Reanne Solly, Sharon Turney, Lyndsay Pearce, William McCormack, S. Pugmire, William Thornley Stoker, Ann Wilson, N Hart, L A Aguilar Jimenez, G Arbane, Sarah Betts, Karen Bisnauthsing, Amy Dewar, Papia Chowdhury, Amy Dewar, G Kaltsakas, Helen Kerslake, M M Magtoto, Pietro Marino, Leonardo Martín Vásquez Martínez, Marlies Ostermann, J Rossdale, T S Solano, Elizabeth Wynn, N Williams, W Storrar, Maria Alvarez Corral, A. Arias, Emily Bevan, Denise Griffin, Jane Martin, J. Owen, Sheila Payne, A Prabhu, Anna Reed, C Wrey Brown, Cathy Lawson, Teresa Burdett, J. Featherstone, A Layton, C Mills, Lorraine Stephenson, Nicholas Easom, Paul Atkin, Khara Croswaite Brindle, Michael G. Crooks, Katie Drury, Rachel Flockton, L Holdsworth, Alicia Richards, Dominic L. Sykes, Susannah Thackray-Nocera, Clinton B. Wright, Keir Lewis, Abdelrahman Mohamed, G Ross, S Coetzee, Katherine Davies, Richard AC Hughes, Ronda Loosley, L O'Brien, Z Omar, Heather McGuinness, Emma Perkins, J Phipps, Abigail Taylor, Helen Tench, R Wolf-Roberts, L S Howard, Onn Min Kon, D C Thomas, S Anifowose, L. Burden, E Calvelo, Brittany Card, Caitlin Carr, Edwin R. Chilvers, Donna R. Copeland, Paul Cullinan, Patricia Daly, Lynsey Evison, T Fayzan, Howard S. Gordon, Sulaimaan Haq, Gísli Jenkins, Christine King, Katherine March, M Mariveles, L McLeavey, N Mohamed, S Moriera, U Munawar, J Nunag, U Nwanguma, L. Orriss-Dib, Amelia Ross, Maxim Roy, Emma Russell, Katie Samuel, J Schronce, Neil Simpson, L Tarusan, C Wood, N Yasmin, Raghunath Reddy, A-M Guerdette, Melissa Hewitt, K Warwick, Simon R. White, Aarti Shah, Caroline J. Jolley, O Adeyemi, R Adrego, H Assefa-Kebede, J Breeze, M Brown, Suzanne Byrne, Trudie Chalder, P Dulawan, Nicholas Hart, Adrian Hayday, A Hoare, A. Knighton, Michael H. Malim, S Patale, I Peralta, Neil Powell, A. Ramos, K Shevket, F Speranza, A Te, Paul Beirne, Andrew Ashworth, Jennifer Clarke, Carol Coupland, Mary E. D’Alton, Erin A. Wade, C Favager, John P. Greenwood, J Glossop, L Hall, T Hardy, A Humphries, Jennifer Murira, D. Peckham, Sven Plein, J Rangeley, G Saalmink, A L Tan, B. Whittam, Nicola Window, Jeffrey A. Woods, G Coakley, Dan Wootton, L Turtle, L. Allerton, A.M. All, Michael Beadsworth, A Berridge, J Brown, Sheldon C. Cooper, Andrew Cross, Sylviane Defres, Susan L. Dobson, J Earley, Neil French, W Greenhalf, H E Hardwick, Kirsten Hainey, Jason E. Hawkes, V Highett, S Kaprowska, A L Key, Lara Lavelle-Langham, N Lewis-Burke, G Madzamba, Flora Malein, S. Marsh, C Mears, L Melling, Maria Noonan, L Poll, John Pratt, E Richardson, Anna Rowe, Malcolm G. Semple, Victoria Shaw, K A Tripp, L O Wajero, S A Williams-Howard, J Wyles, S N Diwanji, Padmasayee Papineni, Sambasivarao Gurram, Sheena Quaid, Gerlynn Tiongson, Eleanor Watson, B Al-Sheklly, A Horsley, Cristina Avram, J Blaikely, Mamta Buch, Noura J. Choudhury, David Faluyi, Timothy Felton, T Gorsuch, N A Hanley, Tracy Hussell, Zunaira Kausar, Natalie Odell, R Osbourne, Karen Piper Hanley, Kavita Radhakrishnan, Skye Stockdale, Anthony De Soyza, C Echevarria, A Ayoub, J Brown, G Burns, Gareth Davies, Helen L. Fisher, C Francis, A Greenhalgh, P Hogarth, Joan Hughes, Kasim Jiwa, Gareth E. Jones, Guy MacGowan, D Price, Avan Aihie Sayer, J Simpson, H Tedd, S Thomas, S West, Miles D. Witham, S Wright, Alison L. Young, Michael McMahon, P Neill, David Anderson, Hannah Bayes, C Berry, D Grieve, Iain B. McInnes, N Basu, Adam D. Brown, Andrew Dougherty, K Fallon, L Gilmour, Kenneth Mangion, Amanda K. Morrow, K Scott, Robert Sykes, Elizabeth K. Sage, Fiona Barrett, A Donaldson, Manthankumar Patel, D Bell, Adam D. Brown, M Brown, R Hamil, K. Leitch, L Macliver, J Quigley, Andrew Smith, B Welsh, Gourab Choudhury, J K Baillie, Sara Clohisey, Andrew Deans, A B Docherty, James Furniss, Ewan M. Harrison, Sarah Kelly, Nazir Lone, A Sheikh, J D Chalmers, David Connell, Angela Elliott, C Deas, Jon C. George, Sarhan Mohammed, J Rowland, A R Solstice, Debbie Sutherland, C J Tee, B Jayaraman, Teresa Light, Charlotte E. Bolton, Paula Almeida, J Bonnington, M Chrystal, C. Dupont, Paul L. Greenhaff, Ayush Gupta, Luke Howard, Wooyoung Jang, S Linford, Lauren Matthews, Robert Needham, A. Nikolaidis, S. Prosper, Karen Shaw, Andrew Thomas, Ling‐Pei Ho, Najib M. Rahman, Mark Ainsworth, Asma Khalid Alamoudi, Andrew Bates, A Bloss, Angus C. Burns, P Carter, J Chen, F Conneh, Tim Dong, Rhodri Evans, Emily Fraser, Xiaotong Fu, J R Geddes, F Gleeson, Paul J. Harrison, May Havinden-Williams, Peter Jezzard, N. Kanellakis, Ivan Koychev, P Kurupati, X Li, Helen McShane, C Megson, K Motohashi, S Neubauer, Debby Nicoll, Graham S. Ogg, Edmund Pacpaco, M Pavlides, Yanchun Peng, Nayia Petousi, Najib M. Rahman, B Raman, Mugsien Rowland, Kathryn J. Saunders, Michael Sharpe, Nick P. Talbot, Elizabeth M. Tunnicliffe, William D‐C Man, Brijesh Patel, Ruth E Barker, D Cristiano, Natalie Dormand, Mahitha Gummadi, Samantha S.C. Kon, Kamal Liyanage, Claire M. Nolan, Suhani Patel, O Polgar, Pallav L. Shah, S J Singh, Jessica A. Walsh, John R. Hurst, Hannah Jarvis, Sema Mandal, Shazaad Ahmad, Simon Brill, L. Lim, Darwin Matila, O Olaosebikan, Chanchal Singh, Mark Toshner, Helen Baxendale, L Garner, Candace Johnson, J Mackie, A Michael, Jamie Pack, Kitty Paques, Helen Parfrey, J Parmar, Nawar Diar Bakerly, Paul Dark, D Evans, E. Hardy, A Harvey, D Holgate, Susan Knight, N Mairs, Nauman Majeed, Liam McMorrow, J Oxton, John Pendlebury, Christina Summersgill, R Ugwuoke, Spence Whittaker, Wadzanai Matimba-Mupaya, Sophia Strong-Sheldrake, Sarah Rowland‐Jones, A A R Thompson, J. Bagshaw, M Begum, K Birchall, Robyn Butcher, H Carborn, Francis K.L. Chan, K Chapman, Yu Cheng, L Chetham, Cameron Clark, Z Coburn, Jason C. Cole, Michael J. Dixon, Andrea D. Fairman, J Finnigan, H Foot, David Foote, James D. Ford, R. Gregory, Kate Harrington, Lynn Haslam‐Larmer, L Hesselden, J Hockridge, A Holbourn, B Holroyd-Hind, L Holt, Alice Howell, E Hurditch, F Ilyas, C Jarman, A Lawrie, E Lee, J-H Lee, R Lenagh, A Lye, Irene Macharia, Michael S. Marshall, A Mbuyisa, J McNeill, S Megson, James Meiring, L Milner, S Misra, Helen Newell, Tom Newman, Chris Norman, Lorenza Nwafor, D Pattenadk, Megan Plowright, J Porter, P Ravencroft, Chloe Roddis, J. Rodger, Peter Saunders, J Sidebottom, Jacqui Smith, Laurie Smith, N Steele, G Stephens, R Stimpson, B Thamu, N Tinker, K. Turner, H. Turton, Phillip Wade, S Walker, James Watson, Iseult Wilson, Amira Zawia, Raminder Aul, Mohammad Ali, A Dunleavy, Daniel Forton, N Msimanga, Mark Mencias, T Samakomva, S Siddique, J Teixeira, Vera Tavoukjian, J Hutchinson, Lynne Allsop, Katherine Bennett, Philip Buckley, M. G. Flynn, Michael Gill, C Goodwin, M Greatorex, H Gregory, Cheryl Heeley, L Holloway, Manisha Holmes, Jodie Kirk, Wayne Lovegrove, T Sewell, Sarah Shelton, D Sissons, Katie Slack, Stephen M. Smith, D. Sowter, Sarah Turner, V Whitworth, Inez Wynter, L Warburton, S Painter, James Tomlinson, Carinna Vickers, Thomas W. Wainwright, Dawn Redwood, J Tilley, S. Palmer, Gwyneth A. Davies, L Connor, Amy Cook, T Rees, Favas Thaivalappil, C Thomas, Adeel A. Butt, M Coulding, H Jones, Susan Kilroy, Jacqueline McCormick, J McIntosh, Heather Savill, Victoria Turner, Joanne Vere, E Fraile, J Ugoji, Samantha S.C. Kon, Harpreet Lota, G Landers, Mariam Nasseri, S Portukhay, Anil Hormis, A Daniels, J Ingham, Lisa Zeidan, Manish Chablani, Lynn Osborne, M Marks, J S Brown, N Ahwireng, B. Bang, D Basire, Rachel C. Chambers, Anna M. Checkley, R. Evans, M Heightman, Toby Hillman, John R. Hurst, J Jacob, Stephanie Janes, R Jastrub, Marc Lipman, Sarah Logan, D Lomas, Marta Merida Morillas, H Plant, Joanna C. Porter, Kaushik Roy, Emma Wall, D Parekh, Nafees Haider, Catherine Atkin, Rob Baggott, M. Bates, A Botkai, Anna Casey, Brendan Cooper, J Dasgin, K Draxlbauer, Nandan Gautam, Jon Hazeldine, T Hiwot, Sara Holden, K Isaacs, Thomas Jackson, S Johnson, Vicky Kamwa, Virginia Lewis, J M Lord, S Madathil, C McGhee, Kirsty McGee, A Neal, A Newton Cox, J Nyaboko, D Parekh, Zhane Peterkin, H Qureshi, L Ratcliffe, Elizabeth Sapey, John Rennie Short, T Soulsby, James Stockley, Z Suleiman, T Thompson, M. Ventura, S Walder, Christopher Welch, Daisy Wilson, S Yasmin, Kay Por Yip, Paul Beckett, Caroline Dickens, Uttam Nanda, C E Brightling, R. Evans, M Aljaroof, Natalie Armstrong, H Arnold, Hnin Aung, M Bakali, M Bakau, Molly M Baldwin, M Bingham, M Bourne, C Bourne, N Brunskill, Paula Cairns, L. Carr, A Charalambou, C D C Christie, M J Davies, Sarah Diver, Sarah Edwards, C Edwardson, Omer Elneima, Helen Evans, J Finch, S Glover, Nigel Goodman, B Gootpu, Neil Greening, Kate Hadley, Pranabashis Haldar, B Hargadon, Victoria Harris, Linzy Houchen-Wolloff, Wadah Ibrahim, L Ingram, K Khunti, A Lea, D Lee, Gerry P McCann, H J C McAuley, P McCourt, T Mcnally, Alastair J. Moss, W Monteiro, Manish Pareek, Sean Parker, A Rowland, A Prickett, Ibraheem Qureshi, R.J. Russell, M Sereno, A Shikotra, Salman Siddiqui, A Singapuri, Sally Singh, J Skeemer, M Soares, Elizabeth M. Stringer, Tracy Thornton, Martin D. Tobin, Louise V. Wain, Tom Ward, Felix Woodhead, T Yates, Ahmed Yousuf, Mark G. Jones, C Childs, Ratko Djukanović, Simon Fletcher, M Harvey, E Marouzet, Ben G. Marshall, R Samuel, Thea Sass, T Wallis, Helen Wheeler, R Dharmagunawardena, E Bright, Philippe Crisp, M Stern, Andrew Wight, L. Charles Bailey, A Reddington, Abdul Ashish, D. James Cooper, Emma Robinson, A Broadley, Kirsten Howard, L Barman, Claire Brookes, Katherine S. Elliott, Lori Griffiths, Z Guy, D Ionita, H Redfearn, C Sarginson, Alison E. Turnbull, Y Ellis, Michael Marks, Andrew Briggs, Katie Holmes, Asthma UK, British Lung, K Poinasamy, S Walker, Mark Halling‐Brown, Gerome Breen, Matthew Hotopf, Keir Lewis, N Williams · 发表于：Brain Communications · 年份：2023 · DOI：10.1093/braincomms/fcad357 · 被引用次数：13 · 研究领域：Long-Term Effects of COVID-19、COVID-19 and Mental Health、Vagus Nerve Stimulation Research

A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and ne...