Characterization and Antibacterial Potential of Iron Oxide Nanoparticles in Eradicating Uropathogenic E. coli

作者：Murad A. Mubaraki, Jaseem Ali, Baharullah Khattak, Fozia Fozia, Taj Ali Khan, Mubbashir Hussain, Madeeha Aslam, Anisa Iftikhar, Ijaz Ahmad · 发表于：ACS Omega · 年份：2023 · DOI：10.1021/acsomega.3c03078 · 被引用次数：11 · 研究领域：Nanoparticles: synthesis and applications、Iron oxide chemistry and applications、Nanoparticle-Based Drug Delivery

High Resolution Image Download MS PowerPoint Slide Proper management and control measurements are needed to stop the spread of highly pathogenic E. coli isolates that cause urinary tract infections (UTI) by developing new antibacterial agents to ensure the safety of public health. Therefore, the present investigations were used to achieve the synthesis of iron oxide nanoparticles (IONPs) via a simple coprecipitation method using ferric nitrates Fe (NO 3 ) 3 as the precursor and hydrazine solution as the precipitator and to explore the antibacterial activity against eradicating Uropathogenic Escherichia coli ( E. coli ). The synthesized IONPs were further studied using a UV–vis spectrophotometer, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopic (SEM) analysis. The maximum surface plasmon resonance peak was observed as absorption at 320 nm in a colloidal solution to validate the synthesis of IONPs. The FT-IR analysis was used to identify different photoactive functional groups that were responsible for the reduction of Fe (NO 3 ) 3 to IONPs. The crystalline nature of synthesized IONPs was revealed by XRD patterns with an average particle size ranging as 29 nm. The SEM image was employed to recognize the irregular morphology of synthesized nanoparticles. Moreover, significant antibacterial activity was observed at 1 mg/mL stock solution but after (125, 250, and 500 μg/mL) dilution, the synthesized IONPs showed moderate a...