Uncovering Brain Network Insights for Prognosis in Disorders of Consciousness: EEG Source Space Analysis and Brain Dynamics

作者：Zexuan Hao, Xiaoyu Xia, Yu Pan, Yang Bai, Yong Wang, Bo Peng, Weibei Dou · 发表于：IEEE Transactions on Neural Systems and Rehabilitation Engineering · 年份：2023 · DOI：10.1109/tnsre.2023.3346947 · 被引用次数：15 · 研究领域：Functional Brain Connectivity Studies、Traumatic Brain Injury Research、Atomic and Subatomic Physics Research

Accurate prognostic prediction in patients with disorders of consciousness (DOC) is a core clinical concern and a formidable challenge in neuroscience. Resting-state EEG has shown promise in identifying electrophysiological prognostic markers and may be easily deployed at the bedside. However, the lack of brain dynamic modeling and the spatial mixture of signals in scalp EEG have constrained our exploration of biomarkers and comprehension of the mechanisms underlying consciousness recovery. Here, we introduce EEG source space analysis and brain dynamics to investigate the brain networks of patients with DOC (n = 178) with different outcomes (six-month follow-up), followed by graph theory and high-order topological analysis to explore the relationship between network structure and prognosis, and finally assess the importance of features. We show that a positive prognosis is associated with large-scale lower levels of low-frequency hypersynchrony. Moreover, we provide evidence that this pattern is driven not by all brain states but only by specific states. Analyses reveal that the positive prognosis is attributed to the network retaining lower segregation, higher integration, and stronger stability compared to the negative prognosis. Furthermore, our results highlight the importance of brain networks derived from brain dynamics in prognosis. The prognosis models based on clinical and neural features can achieve acceptable and even excellent performance under different outcome d...