Cognitive symptoms associated with COVID‐19: neuropsychological and biochemical characterization

作者：Núria Guillén, Agnès Pérez‐Millan, Neus Falgàs Martínez, M. Botí, Adrià Tort‐Merino, Gema María Lledó‐Ibáñez, Raquel Ruiz‐García, Laura Naranjo, Lorena Rami, Roser Sala‐Llonch, Mircea Balasa, Albert Lladó, Raquel Sánchez‐Valle · 发表于：Alzheimer s & Dementia · 年份：2023 · DOI：10.1002/alz.077116 · 研究领域：Long-Term Effects of COVID-19、Cancer-related cognitive impairment studies、COVID-19 and Mental Health

Abstract Background Despite previous studies establishing cognitive impairment as a major complaint in post‐acute COVID‐19 syndrome (PACS), a deeper understanding of the neuropsychological features and underlying causes is needed. We aimed to characterize the cognitive profile of patients affected with cognitive PACS and the influence of biological and psychological factors. Method We performed a prospective single‐center study. We included participants with confirmed SARS‐CoV‐2 infection and long‐term symptoms ≥ 8 weeks after onset who were referred to our unit because of cognitive complaints. All participants completed a comprehensive neuropsychological battery (NPS) and questionnaires assessing depression (Beck Depression Inventory), anxiety (Beck Anxiety Inventory), apathy (Starkstein Apathy Scale) and fatigue (Multidimensional Fatigue Inventory) at baseline and +1, +3 and +6 months. We collected blood samples and cerebrospinal fluid (CSF) to obtain biochemical and immunological profiles. Group comparisons, correlations and Principal component analysis (PCA) were performed. Longitudinal analyses are ongoing. Result Forty‐nine participants were included (79.6% female, mean age 50.1 (SD 7.9). At the time of assessment, they presented multiple symptoms other than cognitive complaints (88% fatigue, 61% headache, 63% dyspnea, and 10% fever). The NPS showed that executive functions were the most affected (up to 29% of the sample had at least one test altered), followed by memor...