Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review

作者：Changhong Wang, Yunchao Liu, Jintai Han, Wenying Li, Jing Sun, Yinan Wang · 发表于：Molecules · 年份：2023 · DOI：10.3390/molecules29010081 · 被引用次数：14 · 研究领域：Nephrotoxicity and Medicinal Plants、Drug-Induced Hepatotoxicity and Protection、Heavy Metals in Plants

Aristolochic acids (AAs) are a toxic substance present in certain natural plants. Direct human exposure to these plants containing AAs leads to a severe and irreversible condition known as aristolochic acid nephropathy (AAN). Additionally, AAs accumulation in the food chain through environmental mediators can trigger Balkan endemic nephropathy (BEN), an environmental variant of AAN. This paper presents a concise overview of the oncogenic pathways associated with AAs and explores the various routes of environmental exposure to AAs. The detection and removal of AAs in natural plants, drugs, and environmental and biological samples were classified and summarized, and the advantages and disadvantages of the various methods were analyzed. It is hoped that this review can provide effective insights into the detection and removal of AAs in the future.