NIR-II-/Tumor Acidity-Triggered Nanoplatform for Precise Chemodynamic/Photodynamic/Hypoxia-Activated Chemo Trimodal Synergistic Therapy

作者：Biao‐Qi Chen, Yi Zhao, Yu-Jing Pan, Da‐Gui Zhang, Hao Liu, Yuhong Shi, Changyong Li, Ranjith Kumar Kankala, Yang Zhang, Shi‐Bin Wang, Gang Liu, Ai‐Zheng Chen · 发表于：ACS Materials Letters · 年份：2023 · DOI：10.1021/acsmaterialslett.3c01070 · 被引用次数：10 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Luminescence and Fluorescent Materials

Engineering stimuli-responsive nanoplatforms for multimodal therapeutics to combat the diversity, complexity, and heterogeneity of malignant tumors has emerged as a new research focus. Herein, chitosan (CS)-based nanoplatforms coloaded with copper selenide quantum dots (Cu 2– x Se QDs) and tirapazamine (TPZ) were prepared by a facile ion-cross-linking method (CS/Cu 2– x Se-TPZ NPs) to achieve stimuli-responsive precise chemodynamic-/photodynamic-/chemotherapy-based trimodal tumor therapy. Triggered by the endogenous tumor acidic microenvironment and the exogenous second near-infrared (NIR-II) light, Cu 2– x Se QDs efficiently generated dreadful radicals (•OH and 1 O 2 ) to achieve efficient Cu 2– x Se-based synergistic chemodynamic therapy (CDT) and photodynamic therapy (PDT). Subsequently, PDT-induced hypoxia activated the cytotoxic potential of TPZ, thus inciting a hypoxia-specific chemotherapeutic effect. The synergistic tumor suppression effect of the trimodal therapy could overcome the hindrance of the tumor microenvironment, showing remarkable therapeutic effects in vitro and in vivo. Together, this work unveiled the potential of engineered stimuli-responsive nanoplatforms by integrating NIR-II-induced PDT, acidity-boosted CDT, and hypoxia-activated chemotherapy, offering potential solutions to current challenges in cancer therapy.