Burden of Uncontrolled Severe Asthma With and Without Elevated Type-2 Inflammatory Biomarkers

作者：Bo Ding, Stephanie Chen, Eleni Rapsomaniki, Anna Quinton, W. James Cook, Helen K. Reddel, Alberto Papi, Ricardo del Olmo, Gary P. Anderson, Helen K. Reddel, Marcelo Fouad Rabahi, Andrew McIvor, Mohsen Sadatsafavi, Ulla Møller Weinreich, Pierre‐Régis Burgel, Gilles Devouassoux, Alberto Papi, Hiromasa Inoue, Adrián Rendón, Maarten van den Berge, Richard Beasley, Àlvar Agustí García-Navarro, Rosa Faner, José Olaguibel Rivera, Christer Janson, Magdalena Bilińska-Izydorczyk, Malin Fagerås, Titti Fihn-Wikander, Stefan Franzén, Christina Keen, Kristoffer Ostridge, James D. Chalmers, Timothy Harrison, Ian Pavord, David Price, Adnan Azim, Laura Belton, François-Xavier Blé, Clement Erhard, Kerry Gairy, Rod Hughes, Glenda Lassi, Hana Müllerová, Eleni Rapsomaniki, Ian Scott, Bradley E. Chipps, Stephanie A. Christenson, Barry J. Make, Erin Tomaszewski, Ricardo del Olmo, Gabriel Benhabib, Xavier Bocca Ruiz, Raúl Lisanti, Gustavo Marino, Walter Mattarucco, Juan Nogueira, Maria Parody, Pablo Pascale, Pablo Rodriguez, Damian Silva, Graciela Svetliza, Carlos Victorio, Roxana Willigs Rolon, Anahí Yáñez, Helen K. Reddel, Stuart Baines, Simon Bowler, Peter Bremner, Sheetal Bull, Patrick Carroll, Mariam Chaalan, Claude S. Farah, Gary Hammerschlag, Kerry Hancock, Zinta Harrington, Gregory Katsoulotos, Joshua Kim, David Langton, Donald Lee, Matthew Peters, Lakshman Prassad, Dimitar Sajkov, Francis Santiago, Frederick Graham Simpson, Sze Tai, Paul S. Thomas, Peter Wark, Marcelo Fouad Rabahi, José Eduardo Delfini Cançado, Thúlio Cunha, Marina Andrade Lima, Alexandre Pinto Cardoso, J. Mark FitzGerald, Andrew McIvor, Syed Anees, John Bertley, Alan Bell, Amarjit Cheema, Guy Chouinard, Michael Csanadi, Anil Dhar, Ripple Dhillon, David Kanawaty, Allan Kelly, William Killorn, Daniel Landry, Robert Luton, Piush J. Mandhane, Bonavuth Pek, Robert Petrella, Daniel Stollery, Chen Wang, Meihua Chen, Yan Chen, Wei Gu, Kim Ming Christopher Hui, Manxiang Li, Shiyue Li, Lijun Ma, Guangyue Qin, Weidong Song, Wei Tan, Yijun Tang, Tan Wang, Fuqiang Wen, Feng Wu, PingChao Xiang, Zuke Xiao, Shengdao Xiong, Jinghua Yang, Jingping Yang, Wei Zhang, Min Zhang, Ping Zhang, Wei Zhang, Xiaohe Zheng, Dan Zhu, Carlos Matiz Bueno, Fabio Bolívar Grimaldos, Alejandra Cañas Arboleda, Dora Molina de Salazar, Ulla Møller Weinreich, Elisabeth Bendstrup, Ole Hilberg, Carsten Kjellerup, Pierre‐Régis Burgel, Gilles Devouassoux, Chantal Rahérison, Philippe Bonniaud, Olivier Brun, C. Chouaïd, Françis Couturaud, J. de Blic, D. Debieuvre, Dominique Delsart, Axelle Demaegdt, Pascal Demoly, A. Deschildre, Carole Egron, Lionel Falchero, François Goupil, Romain Kessler, P. Le Roux, Pascal Mabire, Guillaume Mahay, Stéphanie Martinez, B. Melloni, Laurent Moreau, Emilie Riviere, Pauline Roux-Claudé, Michel Soulier, Guillaume Vignal, Azzedine Yaici, Robert Bals, Sven Philip Aries, Ekkehard Beck, Andreas Deimling, Jan Feimer, Vera Grimm-Sachs, Gesine Groth, Felix Herth, Gerhard Hoheisel, Frank Kanniess, Thomas Lienert, Silke Mronga, Jörg Reinhardt, Christian Schlenska, Christoph Stolpe, Ishak Teber, Hartmut Timmermann, Thomas Ulrich, Peter Velling, Sabina Wehgartner-Winkler, Juergen Welling, Ernst-Joachim Winkelmann, Alberto Papi, Carlo Barbetta, Fulvio Braido, Vittorio Cardaci, Enrico Clini, Maria Teresa Costantino, Giuseppina Cuttitta, Mario Di Gioacchino, Alessandro Giuseppe Fois, Maria Pia Foschino Barbaro, Enrico Gammeri, Riccardo Inchingolo, Federico Lavorini, Antonio Molino, Eleonora Nucera, Vincenzo Patella, Alberto Pesci, Fabio Luigi Massimo Ricciardolo, Paola Rogliani, Riccardo Sarzani, Carlo Vancheri, Rigoletta Vincenti, Hiromasa Inoue, Takeo Endo, Masaki Fujita, Yu Hara, Takahiko Horiguchi, Keita Hosoi, Yumiko Ide, Minehiko Inomata, Koji Inoue, Sumito Inoue, Motokazu Kato, Masayuki Kawasaki, Tomotaka Kawayama, Toshiyuki Kita, Kanako Kobayashi, Hiroshi Koto, Koichi Nishi, Junpei Saito, Yasuo Shimizu, Toshihiro Shirai, Naruhiko Sugihara, Ken-ichi Takahashi, Hiroyuki Tashimo, Keisuke Tomii, Takashi Yamada, Masaru Yanai, Adrián Rendón, Ruth Cerino Javier, Alfredo Domínguez Peregrina, Marco Fernández Corzo, Efraín Montano Gonzalez, Alejandra Ramírez‐Venegas, Maarten van den Berge, Willem Boersma, Remco S. Djamin, Michiel Eijsvogel, Frits Franssen, Martijn Goosens, Lidwien Graat‐Verboom, Johannes in 't Veen, Rob Janssen, Kim Kuppens, Mario van de Ven, Per Bakke, Ole Petter Brunstad, Gunnar Einvik, Kristian Jong Høines, Alamdar Khusrawi, Torbjorn Oien, Ho Joo Yoon, Yoon‐Seok Chang, Young Joo Cho, Yong Il Hwang, Woo Jin Kim, Young‐Il Koh, Byung‐Jae Lee, Kwan-Ho Lee, Sang Pyo Lee, Yong Chul Lee, Seong Yong Lim, Kyung Hun Min, Yeon‐Mok Oh, Choon‐Sik Park, Hae‐Sim Park, Heung‐Woo Park, Chin Kook Rhee, Hyoung-Kyu Yoon, Àlvar Agustí García-Navarro, José Olaguibel Rivera, Rubén Andújar Espinosa, Laura Anoro, María Buendía García, Paloma Campo Mozo, Sergio E. Campos, Francisco Casas Maldonado, Manuel Castilla Martínez, Carolina Cisneros Serrano, Lorena Comeche Casanova, Dolores Corbacho, Felix Del Campo Matías, José Echave-Sustaeta, Gloria Francisco Corral, Pedro Gamboa Setién, Marta García‐Clemente, Ignacio García Núñez, Jose García Robaina, Mercedes García Salmones, José M. Marı́n, Marta Núñez Fernández, Sara Núñez Palomo, Luis Pérez de Llano, Ana Pueyo Bastida, Ana Rañó, José Miguel Rodríguez González-Moro, Albert Roger Reig, José Velasco Garrido, Christer Janson, Dan Curiac, Cornelia Lif-Tiberg, Anders Luts, Lennart Råhlen, Stefan Rustscheff, Timothy Harrison, Frances Adams, Drew Bradman, Emma Broughton, John Cosgrove, Patrick Flood-Page, Elizabeth Fuller, David Hartley, Keith Hattotuwa, Gareth R. Jones, Keir Lewis, Lorcan McGarvey, Alyn H. Morice, Preeti Pandya, Manish Patel, Kay Roy, Ramamurthy Sathyamurthy, S. Thiagarajan, Alice Turner, Jørgen Vestbo, Wisia Wedzicha, Tom Wilkinson, Pete Wilson, Bradley E. Chipps, Lo’Ay Al-Asadi, James D. Anholm, Francis Averill, Sandeep Bansal, Alan P. Baptist, Colin Campbell, Michael Campos, Gretchen Crook, Samuel DeLeon, Alain Eid, Ellen Epstein, Stephen Fritz, Hoadley Harris, Mitzie Hewitt, Fernando Holguín, Golda Hudes, Richard Jackson, Alan Kaufman, David Kaufman, Ari Klapholz, Harshavardhan Krishna, Daria Lee, Robert Y. Lin, Diego Maselli-Caceres, Vinay Mehta, James N. Moy, Ugo Nwokoro, Purvi Parikh, Sudhir Parikh, Frank Perrino, James Ruhlmann, Catherine Sassoon, Russell A. Settipane, Daniel Pereira-Sousa, Peruvemba Sriram, Richard Wachs · 发表于：The Journal of Allergy and Clinical Immunology In Practice · 年份：2023 · DOI：10.1016/j.jaip.2023.12.021 · 被引用次数：8 · 研究领域：Asthma and respiratory diseases、Delphi Technique in Research、Chronic Obstructive Pulmonary Disease (COPD) Research

BACKGROUND: Many patients with asthma have type-2 airway inflammation, identified by the presence of biomarkers, including history of allergy, high blood eosinophil (EOS) count, and high fractional exhaled nitric oxide levels. OBJECTIVE: To assess disease burden in relation to type-2 inflammatory biomarker status (history of allergy, blood EOS count, and fractional exhaled nitric oxide level) in patients with uncontrolled and controlled severe asthma in the NOVEL observational longiTudinal studY (NOVELTY) (NCT02760329). METHODS: Asthma diagnosis and severity were physician-reported. Control was defined using Asthma Control Test score (uncontrolled <20, controlled ≥20) and/or 1 or more severe physician-reported exacerbation in the previous year. Biomarker distribution (history of allergy, blood EOS count, and fractional exhaled nitric oxide level), symptom burden (Asthma Control Test score, modified Medical Research Council dyspnea scale), health status (St George's Respiratory Questionnaire score), exacerbations, and health care resource utilization were assessed. RESULTS: Of 647 patients with severe asthma, 446 had uncontrolled and 123 had controlled asthma. Among those with uncontrolled asthma, 196 (44%) had 2 or more positive biomarkers, 187 (42%) had 1 positive biomarker, 325 (73%) had low blood EOS, and 63 (14%) were triple-negative. Disease burden was similarly high across uncontrolled subgroups, irrespective of biomarker status, with poor symptom control (Asthma Contro...