Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis

作者：Bingbing Cong, Uğurcan Koç, Teresa Bandeira, Quique Bassat, Louis Bont, Giorgi Chakhunashvili, Cheryl Cohen, Christine Desnoyers, Laura L. Hammitt, Terho Heikkinen, Q. Sue Huang, Joško Markić, Ainara Mira‐Iglesias, Jocelyn Moyes, D. James Nokes, Dominique Ploin, Euri Seo, Rosalyn Singleton, Nicole Wolter, Chee Fu Yung, Heather J. Zar, Daniel R. Feikin, Erin Sparrow, Dina Mrčela, Petra Milić, Daniela Veljačić Visković, David Torres-Fernández, Arantxa Urchueguía-Fornes, Javier Díez‐Domingo, Alejandro Orrico‐Sánchez, Sibongile Walaza, Anne von Gottberg, Gary Reubenson, Halima Dawood, Omphile Mekgoe, Mignon du Plessis, Neydis Baute, Fathima Naby, James W. Keck, Jennifer Dobson, Rachel Hartman, Marqia Sandoval, Sara Bressler, Dana Bruden, Irakli Karseladze, Zakhar Shchomak, Rosário Barreto, Nickson Murunga, Martin Mutunga, Jean‐Sébastien Casalegno, Côme Horvat, Harish Nair, You Li · 发表于：The Lancet Infectious Diseases · 年份：2023 · DOI：10.1016/s1473-3099(23)00630-8 · 被引用次数：103 · 研究领域：Respiratory viral infections research、COVID-19 Clinical Research Studies、SARS-CoV-2 detection and testing

BACKGROUND: The COVID-19 pandemic is reported to have affected the epidemiology of respiratory syncytial virus (RSV), which could have important implications for RSV prevention and control strategies. We aimed to assess the hospitalisation burden of RSV-associated acute lower respiratory infection (ALRI) in children younger than 5 years during the pandemic period and the possible changes in RSV epidemiology from a global perspective. METHODS: We conducted a systematic literature search for studies published between Jan 1, 2020, and June 30, 2022, in MEDLINE, Embase, Global Health, Web of Science, the WHO COVID-19 Research Database, CINAHL, LILACS, OpenGrey, CNKI, WanFang, and CqVip. We included unpublished data on RSV epidemiology shared by international collaborators. Eligible studies reported data on at least one of the following measures for children (aged <5 years) hospitalised with RSV-associated ALRI: hospital admission rates, in-hospital case fatality ratio, and the proportion of hospitalised children requiring supplemental oxygen or requiring mechanical ventilation or admission to intensive care. We used a generalised linear mixed-effects model for data synthesis to measure the changes in the incidence, age distribution, and disease severity of children hospitalised with RSV-associated ALRI during the pandemic, compared with the year 2019. FINDINGS: We included 61 studies from 19 countries, of which 14 (23%) studies were from the published literature (4052 identified ...