Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort

作者：Yuan Tian, Yi‐Long Wu, Minjie Qi, Lijuan Song, Bowang Chen, Chunqi Wang, Jiapeng Lu, Yang Yang, Xiaoyan Zhang, Jianlan Cui, Wei Xu, Hao Yang, Wenyan He, Yan Zhang, Xin Zheng, Haibo Zhang, Yuan‐Lin Guo, Xi Li · 发表于：中国科学通报：英文版 · 年份：2023 · DOI：10.1016/j.scib.2023.12.035 · 被引用次数：64 · 研究领域：Cancer, Lipids, and Metabolism、Lipoproteins and Cardiovascular Health、Diabetes, Cardiovascular Risks, and Lipoproteins

The health significance of triglyceride-rich lipoproteins, also known as remnant cholesterol, has been increasingly recognized. However, evidence of their associations with cause-specific mortality in the general population was previously insufficient. To explore these associations and their heterogeneities across subgroups, a prospective cohort study was conducted including 3,403,414 community-based participants from ChinaHEART, an ongoing government-funded public health program throughout China, from November 2014 through December 2022. The study assessed mortality risk of all-cause mortality, cardiovascular disease (CVD) mortality (including mortality from ischemic heart diseases (IHD), ischemic stroke (IS), and hemorrhagic stroke (HS), separately), and cancer mortality (including lung cancer, stomach cancer, and liver cancer, separately). During the 4-year follow-up, 23,646 individuals died from CVD (including 8807 from IHD, 3067 from IS, and 5190 from HS), and 20,318 from cancer (including 6208 from lung cancer, 3013 from liver cancer, and 2174 from stomach cancer). Compared with individuals with remnant cholesterol <17.9 mg/dL, multivariable-adjusted mortality hazard ratios (HRs) for individuals with remnant cholesterol ≥27.7 mg/dL were 1.03 (1.00-1.05) for all-cause mortality, 1.17 (1.12-1.21) for CVD (1.19 (1.12-1.27) for IHD mortality, and 1.22 (1.09-1.36) for IS mortality), and 0.90 (0.87-0.94) for all-cancer mortality (0.94 (0.87-1.02) for lung cancer, 0.59 (0.53-0...