Simultaneous Preparation of Sulfides/Selenides and Sulfones via Synergistic Nickel-Catalyzed Reductive Coupling and SN2 Reaction

作者：Ji-Min Cao, Wei‐Chen Zhu, Xinyu Liu, Weidong Rao, Shusu Shen, Daopeng Sheng, Shun‐Yi Wang · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c03777 · 被引用次数：20 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Organoselenium and organotellurium chemistry

Sulfone compounds and thioether compounds are two highly valuable classes of compounds, but it is challenging to prepare sulfone and thioether compounds simultaneously and efficiently. Here we report that sulfides/selenides and sulfones can be obtained simultaneously using allyl bromide/benzyl bromide-activated alkyl bromides and thiosulfonates/selenosulfonates using a nickel-catalyzed reductive coupling and S N 2 synergistic strategy, which is characterized by excellent atom and step economy, mild reaction conditions, broad functional group compatibility, and excellent yields.