OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3

作者：Xiaoyu Sun, Shuhong Chen, Ying Zhao, Tong Wu, Zheyu Zhao, Wu Luo, Jibo Han, Zimin Fang, Bozhi Ye, Gang Cao, Shengbin Huang, Guang Liang · 发表于：American Journal of Physiology-Cell Physiology · 年份：2023 · DOI：10.1152/ajpcell.00394.2023 · 被引用次数：11 · 研究领域：Renal cell carcinoma treatment、Chronic Kidney Disease and Diabetes、Renal and related cancers

Ovarian tumor domain-containing protein 6 A (OTUD6A) knockout mice are protected against angiotensin II-induced kidney dysfunction and fibrosis. OTUD6A promotes pathological kidney remodeling and dysfunction by deubiquitinating signal transducer and activator of transcription 3 (STAT3). OTUD6A binds to and removes K63-linked-ubiquitin chains of STAT3 to promote its phosphorylation and activation, and subsequently enhances kidney fibrosis.