SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway

作者：Tao Hu, Zhongming Shi, Yongjin Sun, Feng Hu, Yuluo Rong, Jia Wang, Liang Wang, Wenbin Xu, Feng Zhang, Wenzhi Zhang · 发表于：American Journal of Physiology-Cell Physiology · 年份：2023 · DOI：10.1152/ajpcell.00571.2023 · 被引用次数：14 · 研究领域：Spine and Intervertebral Disc Pathology

Selenophosphate synthetase 1 (SEPHS1) deficiency leads to an increase in reactive oxygen species levels and in the subsequent activation of the Hippo-Yap/Taz signaling pathway. In the rat model of intervertebral disc degeneration (IVDD), overexpression of SEPHS1 and inhibition of Hippo-YAP/Taz mitigated the progression of disc degeneration indicating the involvement of SEPHS1 in IVDD. SEPHS1 is a promising therapeutic target for IVDD.