Alterations of oral and gut viromes in hypertension and/or periodontitis

作者：Huilin Ye, Mengfan Zhi, Bo‐Yan Chen, Wen-Zhen Lin, Yulin Li, Shi-Jia Huang, Lu-Jun Zhou, Shuo Xu, Jun Zhang, Wuchang Zhang, Qiang Feng, Sheng‐Zhong Duan · 发表于：mSystems · 年份：2023 · DOI：10.1128/msystems.01169-23 · 被引用次数：16 · 研究领域：Oral microbiology and periodontitis research、HIV/AIDS oral health manifestations、Respiratory viral infections research

ABSTRACT The microbiota plays an important role in both hypertension (HTN) and periodontitis (PD), and PD exacerbates the development of HTN by oral and gut microbiota. Previous studies have focused on exploring the importance of the bacteriome in HTN and PD but overlooked the impact of the virome, which is also a member of the microbiota. We collected 180 samples of subgingival plaques, saliva, and feces from a cohort of healthy subjects (nHTNnPD), subjects with HTN (HTNnPD) or PD (PDnHTN), and subjects with both HTN and PD (HTNPD). We performed metagenomic sequencing to assess the roles of the oral and gut viromes in HTN and PD. The HTNnPD, PDnHTN, and HTNPD groups all showed significantly distinct beta diversity from the nHTNnPD group in saliva. We analyzed alterations in oral and gut viral composition in HTN and/or PD and identified significantly changed viruses in each group. Many viruses across three sites were significantly associated with blood pressure and other clinical parameters. Combined with these clinical associations, we found that Gillianvirus in subgingival plaques was negatively associated with HTN and that Torbevirus in saliva was positively associated with HTN. We found that Pepyhexavirus from subgingival plaques was indicated to be transferred to the gut. We finally evaluated viral-bacterial transkingdom interactions and found that viruses and bacteria may cooperate to affect HTN and PD. Correspondingly, HTN and PD may synergize to improve communications...