Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

作者：Lina Liu, Yihui Chen, Bei Chen, Min Xu, Shuji Liu, Yongchang Su, Kun Qiao, Zhiyu Liu · 发表于：Nutrients · 年份：2023 · DOI：10.3390/nu15245118 · 被引用次数：14 · 研究领域：Seaweed-derived Bioactive Compounds、Fatty Acid Research and Health、Protein Hydrolysis and Bioactive Peptides

Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.