Dimeric N -Acetyldopamine Derivatives Featuring a Seco-Benzene System from the Insects Aspongopus chinensis and Periostracum cicadae

作者：Yong‐Ming Yan, Xing-Hui Bao, Jijun Li, Yan-Peng Li, Haoxing Zhang, Yong‐Xian Cheng · 发表于：Journal of Agricultural and Food Chemistry · 年份：2023 · DOI：10.1021/acs.jafc.3c04851 · 被引用次数：9 · 研究领域：Fungal Biology and Applications、Phytochemical compounds biological activities、Marine Sponges and Natural Products

Aspongamide F ( 1 ), a novel N -acetyldopamine (NADA) dimer possessing a 6/6/6 ring system, and (±)-aspongamides G ( 2 ) and H ( 3 ), rare NADA derivatives with fragmented benzene rings, were isolated from Aspongopus chinensis . (±)-Cicadamides C ( 4 ) and D ( 5 ), the first 1,4-Benzodioxane NADA dimers featuring a seco-benzene system, and (±)-cicadamides E ( 6 ) and F ( 7 ), the NADA dimers derivatives, were isolated from Periostracum cicadae . The structures of all compounds were elucidated by spectroscopic analyses and computational methods. A plausible biosynthetic pathway for compounds 1 – 5 was proposed. The biological assay revealed that (+)– 4 and (−)– 4 exhibit renal protection in a dose-dependent manner.