Molecular Targets of Herbicides and Fungicides─Are There Useful Overlaps for Fungicide Discovery?

作者：Stephen O. Duke, Zhiqiang Pan, Joanna Bajsa‐Hirschel, Prabin Tamang, Raymond Hammerschmidt, Beth A. Lorsbach, Thomas C. Sparks · 发表于：Journal of Agricultural and Food Chemistry · 年份：2023 · DOI：10.1021/acs.jafc.3c07166 · 被引用次数：28 · 研究领域：Fungal Plant Pathogen Control、Pesticide and Herbicide Environmental Studies、Plant Disease Resistance and Genetics

New fungicide modes of action are needed for fungicide resistance management strategies. Several commercial herbicide targets found in fungi that are not utilized by commercial fungicides are discussed as possible fungicide molecular targets. These are acetyl CoA carboxylase, acetolactate synthase, 5-enolpyruvylshikimate-3-phosphate synthase, glutamine synthase, phytoene desaturase, protoporphyrinogen oxidase, long-chain fatty acid synthase, dihydropteroate synthase, hydroxyphenyl pyruvate dioxygenase, and Ser/Thr protein phosphatase. Some of the inhibitors of these herbicide targets appear to be either good fungicides or good leads for new fungicides. For example, some acetolactate synthase and dihydropteroate inhibitors are excellent fungicides. There is evidence that some herbicides have indirect benefits to certain crops due to their effects on fungal crop pathogens. Using a pesticide with both herbicide and fungicide activities based on the same molecular target could reduce the total amount of pesticide used. The limitations of such a product are discussed.