Ligand Promoted Pd-Catalyzed High para-Selective C–H Olefination

作者：Shuo‐Jie Shen, Yaodong Li, Ye Ge, Yang Xu, Linhu Li, Hua‐Jin Xu, Yi Hu · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c03201 · 被引用次数：6 · 研究领域：Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques、Synthesis and Catalytic Reactions

Achieving high para -selective C–H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho -C–H bond. Herein, we report the ligand promoted high para -selective C–H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para -substituted benzoic acid derivatives.