Severe Covid-19 in pregnant and postpartum women admitted to an intensive care unit: A retrospective cohort study

作者：Isabel Cristina Melo Mendes, Ana Luiza Martins de Oliveira, Priscila Martins Pinheiro Trindade, Wallace Mendes‐Silva, Patrícia Pontes Frankel, Carolina Carvalho Mocarzel, M. Rosa, Ana Paula Santos Nascimento, Glaucia de Melo Rodrigues, Clarisse Pimentel, Raissa de Moraes Perlingeiro, Alessandra Gonçalves Lisbôa Pereira, Cláudia Caminha Escosteguy, Rafael Mello Galliez · 发表于：PLoS ONE · 年份：2023 · DOI：10.1371/journal.pone.0295444 · 被引用次数：2 · 研究领域：COVID-19 Impact on Reproduction、Gestational Diabetes Research and Management、Pregnancy and preeclampsia studies

BACKGROUND: SARS-CoV-2 infection is associated with worse maternal and fetal outcomes. This study aims to describe the characteristics of pregnant and postpartum women with severe Covid-19 admitted to ICU. METHODS AND FINDINGS: It's a retrospective cohort study evaluating pregnant and postpartum women referenced to a specialized ICU between May 2020 and June 2022. Covid-19 was confirmed with RT-PCR or rapid antigen test on a nasopharyngeal swab. Variables were described by median and IQR when numerical, and by frequency and percentage when categorical. OR with 95% CI were calculated for the evaluation of factors related to death. P-values were calculated using Pearson's ꭓ2-test, Fisher's exact test, Wilcoxon rank sum test, and Kruskall-Wallis test, and statistical significance was established as < 0·05. Missing data were excluded. All statistical analysis were performed using R software version 4.2.2. Of the 101 admissions, 85 (84·2%) were of pregnant women. Obesity (23·0%) and systemic arterial hypertension (13·0%) were the most prevalent medical conditions. Sixty-six (65·3%) were admitted using some type of oxygen support. Forty-seven (46·5%) evolved to mechanical ventilation. There were 61 events considered obstetric complications, with 8 stillbirths/fetal losses. The overall lethality was 15·8%. Pregnancy interruption, need for non-invasive mechanical ventilation, level of oxygen support at admission, prone maneuver, hemodialysis, and healthcare-related infections were fa...