Effects of exposure to nano-plastic drinking during pregnancy on cognitive related proteins in offspring of SD rats

作者：Jiang Chen, Ya‐Ping Zhang, Xuan Liu, Kang Li, Huanliang Liu, Wenqing Lai, Yue Shi, Zhuge Xi, Licheng Yan, Lei Tian, Bencheng Lin · 发表于：Environmental Pollutants and Bioavailability · 年份：2023 · DOI：10.1080/26395940.2023.2292104 · 被引用次数：17 · 研究领域：Epigenetics and DNA Methylation、MicroRNA in disease regulation、Ferroptosis and cancer prognosis

Nanoplastics, an emerging contaminant, pose risks to fetal neural development, transferring from mother to offspring via placenta and breast milk.Assessing these risks, hippocampal CA3 samples from nanopolystyrene-exposed rat offspring were proteomically analyzed.Findings revealed reduced expression of neural developmental proteins (KIF21A, STMN2, DMTN, DLG1) and increased inhibitory proteins (PZP, α-2M, FN1, SERPINA1, ALOX15) in the hippocampus.Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted ferroptosis enrichment, validated by significantly expressed ALOX15 and TF proteins.These alterations suggest nanopolystyrene's potential contribution to cognitive deficits and neurodevelopmental disorders, emphasizing its hazardous impact on neural development.This study provides novel insights into nanopolystyrene's risks.