Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002

作者：Zhou-Tian-Le Zhang, Sun Hui-bing, Zhen Ren, Tian-Peng Xie, Yingfang Wang, Yin Guo, Xiaoyu Su, Min Yin, Hao Zhou, Zhong‐Tao Ding · 发表于：RSC Advances · 年份：2023 · DOI：10.1039/d3ra07277k · 被引用次数：5 · 研究领域：Genomics and Phylogenetic Studies、Actinomycetales infections and treatment、Myxozoan Parasites in Aquatic Species

. According to genome mining, we isolated actinomycins D and V (1 and 2) and small amounts of 4-methyl-3-hydroxyanthranilic acid (4-MHA) derivates (3 and 4) from strain fermentation broth. The presence of actinrhater A (3) and actinrhater B (4) reveals a mysterious shunt pathway in the early stages of actinomycin D biosynthesis. Our study provides a fresh perspective for further discovery and modification of novel actinomycins.