Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon

作者：James W. King, Aidan S. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan Lomax · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2023 · DOI：10.1152/ajpgi.00230.2023 · 被引用次数：12 · 研究领域：Ion Channels and Receptors、Gastrointestinal motility and disorders、Magnesium in Health and Disease

This is the first study to characterize TRPM3 protein expression and function in colon-projecting DRG neurons. A TRPM3 agonist excited DRG neurons and colonic afferent nerves from healthy mice. TRPM3 agonist responses in DRG neurons were elevated during colitis. Inhibiting TRPM3 reduced the firing of wide dynamic range afferent nerves from mice with colitis but had no effect in control mice.