Synthesis of 2-acyl benzofurans and indoles based on nucleophile-intercepted Meyer–Schuster rearrangement of o -hydroxyphenyl and o -aminophenyl propargylic alcohols

作者：Zhao-Zhao Li, Si-Jing Jiang, Shu-Yun He, Yu‐Ning Gao, Ming Bian, Hui‐Yu Chen, Zhenjiang Liu · 发表于：Organic Chemistry Frontiers · 年份：2023 · DOI：10.1039/d3qo01671d · 被引用次数：15 · 研究领域：Catalytic Alkyne Reactions、Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods

A new type of nucleophile-intercepted Meyer–Schuster rearrangement mediated by pyridine N -oxide under metal-free conditions using a catalytic amount of acid is disclosed. It enables synthesis of 2-acyl benzofurans and indoles in 56–>99% yields.