Age-associated alterations in thalamocortical structural connectivity in youths with a psychosis-spectrum disorder

作者：Lydia Lewis, Mary Corcoran, Kang Ik K. Cho, YooBin Kwak, Rebecca A. Hayes, Bart Larsen, Maria Jalbrzikowski · 发表于：Schizophrenia · 年份：2023 · DOI：10.1038/s41537-023-00411-7 · 被引用次数：9 · 研究领域：Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies、Schizophrenia research and treatment

Abstract Psychotic symptoms typically emerge in adolescence. Age-associated thalamocortical connectivity differences in psychosis remain unclear. We analyzed diffusion-weighted imaging data from 1254 participants 8–23 years old (typically developing (TD): N = 626, psychosis-spectrum (PS): N = 329, other psychopathology (OP): N = 299) from the Philadelphia Neurodevelopmental Cohort. We modeled thalamocortical tracts using deterministic fiber tractography, extracted Q-Space Diffeomorphic Reconstruction (QSDR) and diffusion tensor imaging (DTI) measures, and then used generalized additive models to determine group and age-associated thalamocortical connectivity differences. Compared to other groups, PS exhibited thalamocortical reductions in QSDR global fractional anisotropy (GFA, p -values range = 3.0 × 10 –6 –0.05) and DTI fractional anisotropy (FA, p -values range = 4.2 × 10 –4 –0.03). Compared to TD, PS exhibited shallower thalamus-prefrontal age-associated increases in GFA and FA during mid-childhood, but steeper age-associated increases during adolescence. TD and OP exhibited decreases in thalamus-frontal mean and radial diffusivities during adolescence; PS did not. Altered developmental trajectories of thalamocortical connectivity may contribute to the disruptions observed in adults with psychosis.