Peripheral immunity and risk of incident brain disorders: a prospective cohort study of 161,968 participants

作者：Xiaoling Zhong, Yi‐Xuan Qiang, Ling Wang, Ya-Ru Zhang, Jieqiong Li, Jianfeng Feng, Wei Cheng, Lan Tan, Jin‐Tai Yu · 发表于：Translational Psychiatry · 年份：2023 · DOI：10.1038/s41398-023-02683-0 · 被引用次数：47 · 研究领域：Tryptophan and brain disorders、Fibromyalgia and Chronic Fatigue Syndrome Research、Stress Responses and Cortisol

Whether peripheral immunity prospectively influences brain health remains controversial. This study aims to investigate the longitudinal associations between peripheral immunity markers with incident brain disorders. A total of 161,968 eligible participants from the UK Biobank were included. We investigated the linear and non-linear effects of peripheral immunity markers including differential leukocytes counts, their derived ratios and C-reactive protein (CRP) on the risk of dementia, Parkinson's disease (PD), stroke, schizophrenia, bipolar affective disorder (BPAD), major depressive disorder (MDD) and anxiety, using Cox proportional hazard models and restricted cubic spline models. Linear regression models were used to explore potential mechanisms driven by brain structures. During a median follow-up of 9.66 years, 16,241 participants developed brain disorders. Individuals with elevated innate immunity markers including neutrophils, monocytes, platelets, neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) had an increased risk of brain disorders. Among these markers, neutrophils exhibited the most significant correlation with risk of dementia (hazard ratio 1.08, 95% confidence interval 1.04-1.12), stroke (HR 1.06, 95% CI 1.03-1.09), MDD (HR 1.13, 95% CI 1.10-1.16) and anxiety (HR 1.07, 95% CI 1.04-1.10). Subgroup analysis revealed age-specific and sex-specific associations between innate immunity markers with risk of dementia and MDD. Neuroima...