Research Progress in C—S Coupling Reactions of Aryl Halides

作者：Sining Qin · 发表于：Chinese Journal of Organic Chemistry · 年份：2023 · DOI：10.6023/cjoc202303042 · 被引用次数：11 · 研究领域：Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions、Catalytic C–H Functionalization Methods

Sulfur-containing compounds are widely found in natural products, pharmaceuticals, pesticides, and materials, possessing a variety of biological activities or unique functions.C-S coupling reaction is an important method for the synthesis of sulfur-containing compounds and is one of the hot spots in the field of organic synthesis.With the in-depth development of catalysts and the continuous expansion of sulfur-containing coupling partners, a large number of C-S coupling reactions have emerged in recent years, which greatly facilitate the synthesis of sulfur-containing compounds.Aryl halides are the main kind of substrates for the synthesis of sulfur-containing compounds.C-S coupling reactions of aryl halides and sulfur-containing coupling partners can efficiently afford sulfur-containing compounds, such as thiophenols, thioethers, disulfides and sulfones in different well-designed reaction systems.In this review, the C-S coupling reactions with aryl halides as substrates are reviewed according to the different types of sulfur-containing coupling partners and catalysts (palladium, copper, nickel, and others).The mechanisms of representative reactions are briefly described and compared.In addition, a brief analysis of the current situations and limitations in this field is given, and a prospect for future development is put forward.