United States Value Set for the Functional Assessment of Cancer Therapy-General Eight Dimensions (FACT-8D), a Cancer-Specific Preference-Based Quality of Life Instrument

作者：Madeleine King, Dennis A. Revicki, Richard Norman, Fabiola Müller, Rosalie Viney, A. Simon Pickard, David Cella, James W. Shaw, Neil K. Aaronson, John Brazier, David Cella, Daniel Costa, Peter Fayers, Peter Grimison, Monika Janda, Georg Kemmler, Madeleine King, Nan Luo, Helen McTaggart‐Cowan, Rebecca Mercieca‐Bebber, Richard Norman, Dennis A. Revicki, Stuart Peacock, Simon Pickard, Donna Rowen, Galina Velikova, Rosalie Viney, Deborah J. Street, Tracey Young, Margaret-Ann Tait · 发表于：PharmacoEconomics - Open · 年份：2023 · DOI：10.1007/s41669-023-00448-5 · 被引用次数：12 · 研究领域：Health Systems, Economic Evaluations, Quality of Life、Economic and Financial Impacts of Cancer、Palliative Care and End-of-Life Issues

OBJECTIVES: To develop a value set reflecting the United States (US) general population's preferences for health states described by the Functional Assessment of Cancer Therapy (FACT) eight-dimensions preference-based multi-attribute utility instrument (FACT-8D), derived from the FACT-General cancer-specific health-related quality-of-life (HRQL) questionnaire. METHODS: A US online panel was quota-sampled to achieve a general population sample representative by sex, age (≥ 18 years), race and ethnicity. A discrete choice experiment (DCE) was used to value health states. The valuation task involved choosing between pairs of health states (choice-sets) described by varying levels of the FACT-8D HRQL dimensions and survival (life-years). The DCE included 100 choice-sets; each respondent was randomly allocated 16 choice-sets. Data were analysed using conditional logit regression parameterized to fit the quality-adjusted life-year framework, weighted for sociodemographic variables that were non-representative of the US general population. Preference weights were calculated as the ratio of HRQL-level coefficients to the survival coefficient. RESULTS: 2562 panel members opted in, 2462 (96%) completed at least one choice-set and 2357 (92%) completed 16 choice-sets. Pain and nausea were associated with the largest utility weights, work and sleep had more moderate utility weights, and sadness, worry and support had the smallest utility weights. Within dimensions, more severe HRQL levels...