Effects of RNA methylation on Tumor angiogenesis and cancer progression

作者：Mingyu Han, Haifeng Sun, Quanbo Zhou, Jinbo Liu, Junhong Hu, Weitang Yuan, Zhenqiang Sun · 发表于：Molecular Cancer · 年份：2023 · DOI：10.1186/s12943-023-01879-8 · 被引用次数：71 · 研究领域：RNA modifications and cancer、Cancer-related molecular mechanisms research、RNA Research and Splicing

Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely observed in eukaryotes and prokaryotes. Accumulating studies have revealed that RNA methylation affects the occurrence and development of various tumors. In recent years, RNA methylation has been shown to play an important role in regulating tumor angiogenesis. In this review, we mainly elucidate the mechanisms and functions of RNA methylation on angiogenesis and progression in several cancers. We then shed light on the role of RNA methylation-associated factors and pathways in tumor angiogenesis. Finally, we describe the role of RNA methylation as potential biomarker and novel therapeutic target.