Clavicle fracture in SAPHO syndrome

作者：Yajing Xi, Zhimin Lin, Naigang Chen, Xiujuan Hou, Zhu Yuelan, Chen Li · 发表于：Lara D. Veeken · 年份：2023 · DOI：10.1093/rheumatology/kead640 · 被引用次数：2 · 研究领域：Osteomyelitis and Bone Disorders Research、Bone and Joint Diseases、Infectious Diseases and Tuberculosis

A 21-year-old man developed severe acne on his face and back over a span of >5 years. At the age of 20 years, he began experiencing pain in his right sternoclavicular joint, which was accompanied by limited movement. Subsequently, he was diagnosed with a clavicle fracture. A volume-rendered CT image revealed a fracture in the proximal one-third of the patient’s right clavicle (Fig. 1A). Over time, the fracture gradually healed. However, 2 years later, he once again suffered from chest pain.99mTechnetium-methyl diphosphonate whole-body scintigraphy showed increased radiotracer uptake in the right clavicle, bilateral sternoclavicular joints and the sternal angle (Fig. 1B). A follow-up CT scan indicated that the original fracture line had disappeared, suggesting that the fracture had healed well (Fig. 1C). MRI depicted an old fracture of the sternal end of right clavicle and bone marrow oedema of right sternoclavicular joint (Fig. 1D). As a result of these imaging examinations and his symptoms [1], he was diagnosed with SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome and received zoledronic acid infusion as a treatment. Following the treatment, his pain subsided. This case represents a rare instance of SAPHO syndrome accompanied by a clavicle fracture, wherein the fracture spontaneously occurred and repaired on its own.