Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

作者：Huoying Cai, Lin Huang, Mingshan Wang, Rui-Ming Liu, Jiacong Qiu, Yuansen Qin, Xi Yao, Shenming Wang, Chen Yao, Zuojun Hu, Yu Zhou · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d3fo01235b · 被引用次数：7 · 研究领域：Aortic aneurysm repair treatments、Infectious Aortic and Vascular Conditions、Abdominal vascular conditions and treatments

were used to investigate the role of the miR-146a-5p/TRAF6 axis in the beneficial effect of PTE on macrophage pyroptosis and AAA. We found that PTE inhibited macrophage pyroptosis by miR-146a-5p-mediated suppression of downstream TRAF6 expression. Moreover, miR-146a-5p knockout or TRAF6 overexpression abrogated the protective effect of PTE on macrophage pyroptosis and AAA formation. These findings suggest that miR-146a-5p/TRAF6 axis activation by PTE protects against macrophage pyroptosis and AAA formation. PTE might be a promising agent for preventing inflammatory vascular diseases, including AAA.