KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway

作者：Zhicheng Zhang, Xiaochen Jiang, Kai Li, Shupei Qiao, Mengmeng Li, Mei Yu, Lixian Ding, Qiang Lv, Yike Ding, Yunhan Zhao, Guixiang Lv, Gang Tan, Huanjie Yang, Guodong Li, Xu Gao, Ming Liu · 发表于：International Journal of Biological Sciences · 年份：2023 · DOI：10.7150/ijbs.86385 · 被引用次数：6 · 研究领域：Kruppel-like factors research、Genetic Syndromes and Imprinting、Cancer-related gene regulation

, while KLF7 knockdown attenuated these effects. Mechanistically, our findings reveal that KLF7 can specifically bind to the promoter region of PDGFB (TGGGTGGAG), thus promoting the transcription of PDGFB and increasing its secretion. Subsequently, secreted PDGFB facilitates the progression of COAD by activating MAPK/ERK, PI3K/AKT, and JAK/STAT3 signaling pathways through PDGFRβ. Additionally, we found that sunitinib can block PDGFB signaling and inhibit COAD progression, offering a promising therapeutic strategy for COAD treatment.