Causal relationship between gut microbiota and glioblastoma: a two-sample Mendelian randomization study

作者：Chao Ju, Yanjing Chen, Longtao Yang, Yi‐Jie Huang, Jun Liu · 发表于：Journal of Cancer · 年份：2023 · DOI：10.7150/jca.90149 · 被引用次数：7 · 研究领域：Gut microbiota and health、Cancer-related molecular mechanisms research

Background: Observational research and medical trials have suggested a connection between gut microbiota and glioblastoma, but it remains unclear if the relationship is causal. Method: A two-sample Mendelian randomization (MR) study was conducted by employing data from the MiBioGen consortium's largest genome-wide association study (n=18340) and the FinnGen consortium R8 release information (162 cases and 256,583 controls). Inverse variance weighted (IVW), weighted median estimator (WME), weighted model, MR-Egger, simple mode, and MR-PRESSO were used to determine the causal relationship between gut microbiota and glioblastoma. Reverse MR analysis was also performed on bacteria identified as causally related to glioblastoma. Results: Seven causal relationships were identified between genetic liability in the gut microbiota and glioblastoma, involving various bacterial families and genera. No significant causal effect was found on gut microbiota from glioblastoma, and no significant heterogeneity of instrumental variables (IVs) or horizontal pleiotropy was observed.