Interactive Association Between Gut Microbiota and Thyroid Cancer

作者：Tianzhichao Hou, Qi Wang, Huajie Dai, Yanan Hou, Jie Zheng, Tiange Wang, Hong Lin, Shuangyuan Wang, Mian Li, Zhiyun Zhao, Yuhong Chen, Yu Xu, Jieli Lu, Ruixin Liu, Guang Ning, Weiqing Wang, Min Xu, Yufang Bi · 发表于：Endocrinology · 年份：2023 · DOI：10.1210/endocr/bqad184 · 被引用次数：14 · 研究领域：Gut microbiota and health、Thyroid Cancer Diagnosis and Treatment、Ferroptosis and cancer prognosis

CONTEXT: The association between the gut microbiota and thyroid cancer remains controversial. OBJECTIVE: We aimed to systematically investigate the interactive causal relationships between the abundance and metabolism pathways of gut microbiota and thyroid cancer. METHODS: We leveraged genome-wide association studies for the abundance of 211 microbiota taxa from the MiBioGen study (N = 18 340), 205 microbiota metabolism pathways from the Dutch Microbiome Project (N = 7738), and thyroid cancer from the Global Biobank Meta-analysis Initiative (N cases = 6699 and N participants = 1 620 354). We performed a bidirectional Mendelian randomization (MR) to investigate the causality from microbiota taxa and metabolism pathways to thyroid cancer and vice versa. We performed a systematic review of previous observational studies and compared MR results with observational findings. RESULTS: Eight taxa and 12 metabolism pathways had causal effects on thyroid cancer, where RuminococcaceaeUCG004 genus (P = .001), Streptococcaceae family (P = .016), Olsenella genus (P = .029), ketogluconate metabolism pathway (P = .003), pentose phosphate pathway (P = .016), and L-arginine degradation II in the AST pathway (P = .0007) were supported by sensitivity analyses. Conversely, thyroid cancer had causal effects on 3 taxa and 2 metabolism pathways, where the Holdemanella genus (P = .015) was supported by sensitivity analyses. The Proteobacteria phylum, Streptococcaceae family, Ruminococcus2 genus, and ...