Low Bone Mineral Density and the Risk of Benign Paroxysmal Positional Vertigo

作者：Junhong Li, Libo Yu, Ping An, Wendu Pang, Xiaohong Yan, Di Deng, Yao Song, Minzi Mao, Ke Qiu, Yufang Rao, Danni Cheng, Yuyang Zhang, Lan Feng, Xiaoyu Wang, Ziyan Zhang, Yongbo Zheng, Wei Xu, Jianjun Ren, Yu Zhao · 发表于：Otolaryngology · 年份：2023 · DOI：10.1002/ohn.600 · 被引用次数：10 · 研究领域：Vestibular and auditory disorders、Balance, Gait, and Falls Prevention、High Altitude and Hypoxia

OBJECTIVE: This study aimed to comprehensively analyze the relationship between low bone mineral density (BMD) and the risk of benign paroxysmal positional vertigo (BPPV) based on the large prospective population-based UK Biobank (UKB) cohort. STUDY DESIGN: Prospective population-based cohort study. SETTING: The UKB. METHODS: This prospective cohort study included UKB participants recruited between 2006 and 2010 who had information on BMD and did not have BPPV before being diagnosed with low BMD. Univariable and multivariable logistic regression models were constructed to assess the association between low BMD (overall low BMD, osteopenia, and osteoporosis) and BPPV. We further conducted sex and age subgroup analysis, respectively. Finally, the effects of antiosteoporosis and female sex hormone medications on BPPV in participants with osteoporosis were evaluated. RESULTS: In total, 484,303 participants were included in the final analysis, and 985 developed BPPV after a maximum follow-up period of 15 years. Osteoporosis was associated with a higher risk of BPPV (odds ratio [OR] = 1.37, P = .0094), whereas osteopenia was not. Subgroup analyses suggested that the association between osteoporosis and BPPV was significant only in elderly females (≥60 years, OR = 1.51, P = .0007). However, no association was observed between antiosteoporosis or female sex hormone medications and BPPV in the participants with osteoporosis. CONCLUSION: Osteoporosis was associated with a higher risk o...