Integrating direct electrical brain stimulation with the human connectome

作者：Ludovico Coletta, Paolo Avesani, Luca Zigiotto, Martina Venturini, Luciano Annicchiarico, Laura Vavassori, Sam Ng, Hugues Duffau, Silvio Sarubbo · 发表于：Brain · 年份：2023 · DOI：10.1093/brain/awad402 · 被引用次数：28 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Advanced Neuroimaging Techniques and Applications

Neurological and neurodevelopmental conditions are a major public health concern for which new therapies are urgently needed. The development of effective therapies relies on the precise mapping of the neural substrates causally involved in behaviour generation. Direct electrical stimulation (DES) performed during cognitive and neurological monitoring in awake surgery is currently considered the gold standard for the causal mapping of brain functions. However, DES is limited by the focal nature of the stimulation sites, hampering a real holistic exploration of human brain functions at the network level. We used 4137 DES points derived from 612 glioma patients in combination with human connectome data-resting-state functional MRI, n = 1000 and diffusion weighted imaging, n = 284-to provide a multimodal description of the causal macroscale functional networks subtending 12 distinct behavioural domains. To probe the validity of our procedure, we (i) compared the network topographies of healthy and clinical populations; (ii) tested the predictive capacity of DES-derived networks; (iii) quantified the coupling between structural and functional connectivity; and (iv) built a multivariate model able to quantify single subject deviations from a normative population. Lastly, we probed the translational potential of DES-derived functional networks by testing their specificity and sensitivity in identifying critical neuromodulation targets and neural substrates associated with postopera...