Kinetic modeling and parametric imaging of 18 F‐PSMA‐11: An evaluation based on total‐body dynamic positron emission tomography scans

作者：Hui Yuan, Guojin Zhang, Taotao Sun, Jingyun Ren, Qing Zhang, Zeyin Xiang, Entao Liu, Lei Jiang · 发表于：Medical Physics · 年份：2023 · DOI：10.1002/mp.16876 · 被引用次数：12 · 研究领域：Prostate Cancer Treatment and Research、Medical Imaging Techniques and Applications、Radiopharmaceutical Chemistry and Applications

Abstract Background The prostate‐specific membrane antigen (PSMA) targeted positron‐emitting tomography (PET) tracers are increasingly used in clinical practice, with novel tracers constantly being developed. Recently, 18 F‐PSMA‐11 has been gaining growing interest for several merits; however, direct in vivo visualization of its kinetic features in humans remains lacking. Purpose To visualize the kinetic features of 18 F‐PSMA‐11 in healthy subjects and patients with prostate cancer derived from the total‐body dynamic PET scans. Methods A total of 8 healthy volunteers (7 males; 1 female) and 3 patients with prostate cancer underwent total‐body PET/CT imaging at 1 and 2 h post injection (p.i.) of 18 F‐PSMA‐11, of which 7 healthy subjects and 3 patients underwent total‐body dynamic PET scans lasting 30 min. Reversible two‐tissue compartments (2TC) and Patlak models were fitted based on the voxel‐based time activity curves (TACs), with the parametric images generated subsequently. Additionally, semi‐automated segmentation of multiple organs was performed in the dynamic images to measure the SUVmean at different time points and in the parametric images to estimate the mean value of the kinetic parameters of these organs. Results 18 F‐PSMA‐11 showed quick accumulation within prostate cancer, as early as 45 s after tracer injection. It was rapidly cleared from blood circulation and predominantly excreted through the urinary system. High and rapid radiotracer accumulation was observe...