Efficacy of antimicrobial and nutraceutical treatment for canine acute diarrhoea: A systematic review and meta-analysis for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines

作者：Karolina Scahill, Lisbeth Rem Jessen, Cameron Prior, David Singleton, Farid Foroutan, Aude A. Ferran, Carolina Arenas, Charlotte Reinhard Bjørnvad, Eran Lavy, Fergus Allerton, Jeffrey Scott Weese, Karin Allenspach, Luca Guardabassi, Stefan Unterer, T. Bodnárová, Ulrika Windahl, Marnie Louise Brennan, Melanie Werner · 发表于：The Veterinary Journal · 年份：2023 · DOI：10.1016/j.tvjl.2023.106054 · 被引用次数：34 · 研究领域：Clostridium difficile and Clostridium perfringens research、Gut microbiota and health、Viral gastroenteritis research and epidemiology

Systemic antimicrobial treatments are commonly prescribed to dogs with acute diarrhoea, while nutraceuticals (prebiotics, probiotics, and synbiotics) are frequently administered as an alternative treatment. The aim of this systematic review and meta-analysis was to assess the effectiveness of antimicrobials and nutraceutical preparations for treatment of canine acute diarrhoea (CAD). The results of this study will be used to create evidence-based treatment guidelines. PICOs (population, intervention, comparator, and outcome) were generated by a multidisciplinary expert panel taking into account opinions from stakeholders (general practitioners and dog owners). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to evaluate the certainty of the evidence. The systematic search yielded six randomised controlled trials (RCT) for antimicrobial treatment and six RCTs for nutraceutical treatment meeting the eligibility criteria. Categories of disease severity (mild, moderate, and severe) were created based on the presence of systemic signs and response to fluid therapy. Outcomes included duration of diarrhoea, duration of hospitalization, progression of disease, mortality, and adverse effects. High certainty evidence showed that antimicrobial treatment did not have a clinically relevant effect on any outcome in dogs with mild or moderate disease. Certainty of evidence was low for dogs with severe disease. Nutraceutical products did not ...