Mycoplasma pneumoniae detections in Children with lower respiratory infection before and during the COVID-19 pandemic: a large sample study in China from 2019-2022

作者：Weiling Qiu, Jiaying Ding, Homgmei Zhang, Shumin Huang, Zuowei Huang, Ming Lin, Yuanyuan Zhang, Zhimin Chen · 发表于：Research Square · 年份：2023 · DOI：10.21203/rs.3.rs-3625894/v1 · 被引用次数：1 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、Microbial infections and disease research

Abstract Background Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also suppressed the spread the other respiratory viruses during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to explore the epidemiological trend and clinical characteristics of Mycoplasma pneumoniae (MP) infection among inpatient children with lower respiratory tract infection (LRTI) before and during COVID-19 pandemic, and to investigate the long-term effects of the China’s NPIs against COVID-19 on the epidemiology of MP among inpatient children with LRTI. Methods Common respiratory pathogens were detected in hospitalized children due to LRTI at the Department of pulmonology, The Children’s Hospital, Zhejiang University School of Medicine(Hangzhou, China) from January 2019 to December 2022. All respiratory specimens were tested for seven common viruses, Mycoplasma pneumonia(MP), Chlamydia trachomatis༈CT༉and bacteria. The clinical data of age, gender, season of onset, disease spectrum and combined infection in children with MP induced LRTI in the past 4 years were collected and analyzed. Results A total of 15909 patients were enrolled, and MP positive cases were 1971(34.0%), 73(2.4%), 176(5.8%), 952(20.6%) in 2019, 2020, 2021,2022, respectively, with a significant statistical difference of the MP positive rate among the 4 years(p < 0.001). The median age of these children was pre-school age (>...