Dysregulated neural activity between the thalamus and cerebral cortex mediates cortical reorganization in cervical spondylotic myelopathy

作者：Jianchao Chang, Kun Zhu, Siya Zhang, Ying Wang, Yan Li, Junxun Zuo, Bing Xie, Haoyu Ni, Jiyuan Yao, Zhibin Xu, Tingfei Yan, Xianyong Wu, Senlin Chen, Peng Xu, Peiwen Song, Yuanyuan Wu, Jiajia Zhu, Cailiang Shen, Yongqiang Yu, Fulong Dong · 发表于：Brain Research Bulletin · 年份：2023 · DOI：10.1016/j.brainresbull.2023.110837 · 被引用次数：7 · 研究领域：Cervical and Thoracic Myelopathy、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

Neuroimaging research has revealed significant changes in brain structure and function in patients with cervical spondylotic myelopathy(CSM). The thalamus plays a crucial role in this process, although its mechanisms of action remain incompletely understood. This study aimed to investigate whether spinal cord compression leads to alterations in the functional connectivity between the thalamus and the cerebral cortex, and to determine if such changes are associated with structural and functional remodeling of the brain in patients with CSM, and to identify potential neuroimaging biomarkers for classification. The study included 40 patients with CSM and 34 healthy controls(HCs) who underwent resting-state functional magnetic resonance imaging(fMRI) and structural MRI scans. Brain structural and functional metrics were quantified using functional connectivity(FC), fractional amplitude of low-frequency fluctuations(fALFF), surface-based morphometry(SBM), and independent component analysis(ICA) based on functional and structural MRI. Patients with CSM exhibited significantly reduced fALFF in the bilateral lateral lingual gyrus, bilateral calcarine fissure, left precentral gyrus and postcentral gyrus, left middle and superior occipital gyrus, left superior marginal gyrus, left inferior parietal gyrus, and right Rolandic operculum. ICA results revealed weakened functional connectivity between the sensorimotor network (SMN) and the left and right frontoparietal network(FPN), and late...