Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia

作者：Mehdi Benlarbi, Jonathan Richard, Catherine Bourassa, William D. Tolbert, Carl Chartrand‐Lefebvre, Gabrielle Gendron‐Lepage, Mohamed Sylla, Mohamed El‐Far, Marc Messier-Peet, Camille Guertin, Isabelle Turcotte, Rémi Fromentin, Myriam Maude Verly, Jérémie Prévost, Andrew Clark, Walther Mothes, Daniel E. Kaufmann, Frank Maldarelli, Nicolas Chomont, Philippe Bégin, Cécile Tremblay, Jean-Guy Baril, Benoît Trottier, Sylvie Trottier, Ralf Duerr, Marzena Pazgier, Madéleine Durand, Andrés Finzi · 发表于：The Journal of Infectious Diseases · 年份：2023 · DOI：10.1093/infdis/jiad503 · 被引用次数：33 · 研究领域：HIV-related health complications and treatments、HIV Research and Treatment、Atherosclerosis and Cardiovascular Diseases

BACKGROUND: Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, showing immunomodulatory properties even in the absence of detectable viremia. We evaluated whether plasma soluble gp120 (sgp120) and a family of gp120-specific anti-cluster A antibodies, linked to CD4 depletion in vitro, contribute to chronic inflammation, immune dysfunction, and subclinical cardiovascular disease in participants of the Canadian HIV and Aging Cohort Study with undetectable viremia. METHODS: Cross-sectional assessment of sgp120 and anti-cluster A antibodies was performed in 386 individuals from the cohort. Their association with proinflammatory cytokines and subclinical coronary artery disease was assessed using linear regression models. RESULTS: High levels of sgp120 and anti-cluster A antibodies were inversely correlated with CD4+ T cell count and CD4/CD8 ratio. The presence of sgp120 was associated with increased levels of interleukin 6. In participants with detectable atherosclerotic plaque and detectable sgp120, anti-cluster A antibodies and their combination with sgp120 levels correlated positively with the total volume of atherosclerotic plaques. CONCLUSIONS: This study showed that sgp120 may act as a pan toxin causing immune dysfunction and sustained inflammation in a subset of people livin...