Characteristics of inflammatory phenotypes in patients with chronic obstructive pulmonary disease: a cross-sectional study

作者：Xiang Wen, Zhishan Deng, Jieqi Peng, Huajing Yang, Fan Wu, Cuiqiong Dai, Youlan Zheng, Ningning Zhao, Zihui Wang, Shan Xiao, Jianwu Xu, Lifei Lu, Xiaohui Wu, Kunning Zhou, Jianwei Dai, Bing Li, Pixin Ran, Yumin Zhou · 发表于：BMJ Open Respiratory Research · 年份：2023 · DOI：10.1136/bmjresp-2022-001454 · 被引用次数：19 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases、Delphi Technique in Research

BACKGROUND: The relationship between airway inflammation in chronic obstructive pulmonary disease (COPD) and clinical characteristics remains unclear. This study aimed to investigate the airway inflammatory phenotypes in COPD and their association with clinical characteristics. METHODS: 895 patients with COPD were recruited from Guangdong Province, China in this study. Each patient underwent questionnaire interviews, spirometry testing, CT scans and induced sputum examination. Classification of airway inflammation phenotypes was based on sputum inflammatory cell counts. Covariance analysis was applied to assess associations with airway inflammation phenotypes. RESULTS: In this study, we found that neutrophilic phenotype (NP, 58.0%) was the most common airway inflammation phenotype in patients with COPD, followed by mixed granulocytic phenotype (MGP, 32.6%), eosinophilic phenotype (EP, 5.4%) and paucigranulocytic phenotype (PP, 4.0%). Compared with NP patients, those with MGP exhibited more frequent chronic respiratory symptoms, and a higher proportion of individuals classified under Global Initiative for Chronic Obstructive Lung Disease stages 3 and 4. After adjusting for confounding factors, MGP patients had lower lung function, and more severe emphysema and air trapping. On the contrary, patients with PP had the best pulmonary function and less emphysema and air trapping. CONCLUSIONS: NP was the most common airway inflammation phenotype in patients with COPD. Patients with ...