COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss

作者：Janneke A C van Baar, Elena Kostova, John Allotey, Shakila Thangaratinam, Javier R Zamora, Mercedes Bonet, Caron Rahn Kim, Lynne Mofenson, Heinke Kunst, Asma Khalil, Elisabeth van Leeuwen, Julia Keijzer, Marije Strikwerda, B. A. Clark, Maxime Verschuuren, Arri Coomarasamy, Mariëtte Goddijn, Madelon van Wely, Elena Stallings, Magnus Yap, Shaunak Chatterjee, Tania Kew, Luke Debenham, Anna Clavé Llavall, Anushka Dixit, Dengyi Zhou, Rishab Balaji, Xiu Qiu, Mingyang Yuan, Dyuti Coomar, Siang Ing Lee, Vanessa Brizuela, Nathalie Broutet, Edna Kara, Caron Rahn Kim, Anna Thorson, Olufemi T. Oladapo · 发表于：Human Reproduction Update · 年份：2023 · DOI：10.1093/humupd/dmad030 · 被引用次数：34 · 研究领域：COVID-19 Impact on Reproduction、Maternal Mental Health During Pregnancy and Postpartum、Reproductive System and Pregnancy

BACKGROUND: Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal unit. The World Health Organization declared in May 2023 an end to the coronavirus disease 2019 (COVID-19) pandemic as a global health emergency. However, pregnant women are still becoming infected with SARS-CoV-2 and there is limited information available regarding the effect of SARS-CoV-2 infection in early pregnancy on pregnancy outcomes. OBJECTIVE AND RATIONALE: We conducted this systematic review to determine the prevalence of early pregnancy loss in women with SARS-Cov-2 infection and compare the risk to pregnant women without SARS-CoV-2 infection. SEARCH METHODS: Our systematic review is based on a prospectively registered protocol. The search of PregCov19 consortium was supplemented with an extra electronic search specifically on pregnancy loss in pregnant women infected with SARS-CoV-2 up to 10 March 2023 in PubMed, Google Scholar, and LitCovid. We included retrospective and prospective studies of pregnant women with SARS-CoV-2 infection, provided that they contained information on pregnancy losses in the first and/or second trimester. Primary outcome was miscarriage defined as a pregnancy loss before 20 weeks of gestation, however, studies that reported loss up to 22 or 24 weeks were also included. Additionally, we report on studies that defined t...