Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

作者：Jialiang Sun, Pei‐Liang Zhao, Ying Shi, Yanan Li · 发表于：Frontiers in Cell and Developmental Biology · 年份：2023 · DOI：10.3389/fcell.2023.1292016 · 被引用次数：21 · 研究领域：Alcohol Consumption and Health Effects、Immune cells in cancer、Sphingolipid Metabolism and Signaling

Alcohol-associated liver disease (ALD) is a condition that develops due to prolonged and excessive alcohol consumption. It encompasses various stages of liver damage, including fatty liver, alcoholic hepatitis, and cirrhosis. Immune cells, particularly macrophages, of various types play a significant role in the onset and progression of the disease. Macrophages observed in the liver exhibit diverse differentiation forms, and perform a range of functions. Beyond M1 and M2 macrophages, human macrophages can polarize into distinct phenotypes in response to various stimuli. Recent advancements have improved our understanding of macrophage diversity and their role in the progression of ALD. This mini-review provides a concise overview of the latest findings on the role and differentiation of macrophages in ALD. Additionally, it discusses potential therapeutic targets associated with macrophages and explores potential therapeutic strategies.